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Academia Mexicana de Neurología, A.C.

2009, Number 1

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Rev Mex Neuroci 2009; 10 (1)

The mannose receptor: the non-infectious HIV-1 pathway

Jileta A, Trujillo JR

Language: Spanish
References: 45
Page: 44-48
PDF size: 74.78 Kb.


ABSTRACT

Although protein receptors on the plasma membrane involved in the initial steps of productive HIV-1 infection have been well characterized, little is known about interactions between cellular carbohydrate receptors and HIV-1. Here, in this review we described the involvement of a carbohydrate receptor, the macrophage mannose receptor (MR), and its role in supporting HIV- 1 binding and entry. Our studies suggest that while MR may serve as a binding and an entry site, the MR-mediated pathway does not lead to productive HIV-1 infection. Therefore, characterization of the HIV-1 non-infectious MR-mediated phagocytic pathway may foster advances in HIV-1 vaccine design and an improved understanding of HIV-1/AIDS pathogenesis and host defenses.


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