medigraphic.com
Academia Mexicana de Neurología, A.C.

2008, Number 3

<< Back Next >>

Rev Mex Neuroci 2008; 9 (3)

Guillain-Barré syndrome as paraneoplastic manifestation of Non-Hodgkin lymphoma: Case report

Gutiérrez LC, Plascencia ÁNI, Quiñones AS, Venegas TA, Núñez OL

Language: Spanish
References: 8
Page: 239-241
PDF size: 145.94 Kb.


ABSTRACT

We present the case of a 59 years-old male with clinical features of acute demyelinating polyneuropathy with distal sensitive alterations, weight loss, axillary adenopathies, painful hepatosplenomegaly and widen mediastinum demonstrated by CT scan. Axillary lymph node biopsy showed follicular lymphoma grade II (no Hodgkin). Guillain-Barre syndrome is an acquired inflammatory disease produced by an immunological mechanism associated to Campylobacter jejunii and some viruses. Peripheral neuropathies associated to non-Hodgkin malignant lymphomas are commonly due to drug toxicity or infiltration to nervous system or both, but the paraneoplastic association is less than 3%, reason to present this case.


REFERENCES

  1. Re, D. Schwenk A, et al. Guillain-Barré syndrome in a patient with non Hodgkin´s lymphoma. Annaks if incology II. 2000, p. 217-20.

  2. Dalmau J, Gultekin MS. Paraneoplastic neurologic syndromes; pathogenesis and physiopathology. Brain Pathol 1999; 9: 275-84.

  3. Damian JO, Posner JB. Paraneoplasic síndromes affecting the nervious system. Semen Oncol 1997; 24: 318-28.

  4. Bataller L, Dalmau J. Paraneoplasic neurologic syndromes. Neurol Clin N Am 2003; 21: 221-47.

  5. Bosch EP. Guillain-Barré syndrome: an update of acute immune mediated polyradiculoneuropathies. The Neurologist. Vol. 4.: 1998; 211-26.

  6. Haubenstock A, Base W, Bettelheim P, et al. Malignant histiocytosis with unusual features. Disseminated intravascular coagulation with severe hyperfibrinolysis, acute polyneuroradiculitis Guillain-Barré and unique chromosome abnormality. Cancer 1984; 53: 1574-8.

  7. Johnson NT, Crawford SW. Acute adquired demyelinating polyneuropathy with respiratory failure following high dose systemic cytosine arabinoside and marrow transplantation bone. Marrow Transplant 1987; 2: 203-7.

  8. Zuk Ewa, Pzemyslaw N. Guillain-Barré syndrome in patient with Burkitt’s lymphoma and type 2 diabetes mellitus. Folia Neuropathol; 39(4): 280-4.




2020     |     www.medigraphic.com