Andrade MR

Language: Spanish
References: 35
Page: 350-359
PDF size: 70.82 Kb.

ABSTRACT

Introduction: Both cognitive regression and behaviour disorders had been associated with gabaergic antiepileptic medication in patients with rolandic epilepsy, nevertheless the cause-effect relation of this phenomenon had not been evaluating. Objective: To describe the clinical and functional evolution of patients with Benign Childhood Epilepsy of Infancy with centro-temporal spikes without antiepileptic medication until presentation of complications. Patients and method: A group of 45 patients with rolandic epilepsy were assessed with clinical and serial sleep and wake electroencephalograms, Single Photon Emission Tomography and Neuropsychological tests. The patients were followed from the diagnosis up to they presented complications such as: cognitive deficits, electrical status during slow sleep and cluster seizures. Neuropsychological skills were compared with those of a group of childen of similar age and sex (control group). P&#‹0.05 value was considered as significant. Results: The study included 45 children, 17 had cluster seizures, 11 showed electrical status during slow wave sleep and 14 had cognitive deficits. All complication were found in patients without antiepileptic medication. Conclusions: Complicate variants of rolandic epilepsy depend on genetic subtypes with variable phenotypic expression. Gabaergic antiepileptic drugs could be a trigger factor acting in special genetically predisposed patients but they are not the cause.

REFERENCES

1. D’alexandro P, Piccirilli M, Tiscci C, Ibba A, Maiotti M, Sciarma T. Neuropsychological features of benign partial epilepsy in children. Ital J Neurol Sci 1990; 11: 265-9.

2. Deonna T, Zesiger P, Davidoff V, Maeder M, Muyor C, Roulet E. Benign partial epilepsy of childhood: a longitudinal Neuropsychological and EEG study of cognitive function. Der Med Child Neurol 2000; 42: 595-603.

3. Robinson RJ. Causes and associations of severe and persistent specific speech and language disorders in children. Dev Med Child Neurol 1991; 33: 943-62.

4. Weglage J, Demsky A, Pietsch M, Kurlemmann G. Neuropsychological, intelectual, and behavioral findings in patient with centro-temporal spikes with and without Seizures. Dev Med Child Neurol 1997; 39: 646-51.

5. Klein SK, Tuchman RF, Rapin I. The influence of premorbid language skills and behavior on language recovery in children with verbal audito y agnosia. J Child Neurol 2000; 15: 36-43.

6. Commission on clasification and terminology of the international Laegue Againt Epilepsy. Proposal for revised clasification of epilepsies and epileptic syndromes. Epilepsia 1989; 30: 389-99.

7. Commision on Epidemiology and prognosis, International League Againt Epilepsy. Guidelines for epidemiological studies on epilepsy. Epilepsia 1993; 34: 592-6.

8. Swanson JM, Sergeant JS, Taylor E, Sonuga-Barke EJ. Attention deficit hyperactivity disorder and hyperkinetic disorder. Lancet 1998; 351: 429-33.

9. Wechsler D. Manual for the Wechsler Intelligence Scale for Children. 3rd. Ed. San Antonio: The Psychological Corporation; 1991.

10. Dubois CM, Zesiger P, Pérez ER, et al. Acquired epileptic dysgraphia: a longitudinal study. Dev Med Child Neurol 2003; 45: 807-12.

11. Casa-Fernández C. Aspectos más recientes de la genética de las epilepsias. Rev Neurol 2000; 30(Suppl. 1): S46-S59.

12. Carlsson G, Igelbrink-Schulze N, Neubauer BA, Stephani U. Neuropsychological longterm outcome of Rolandic EEG traits. Epileptic Disord 2000; 2(Suppl. 1): S636.

13. Gunduz E, Demirbilek V, Korkmaz B. Benign Rolandic epilepsy: neuropsychological findings. Seizure 1999; 8: 24- 69.

14. Ong HT, Wyllie E. Benign childhood epilepsy with centrotemporal spikes: is it always benign? Neurology 2000; 54: 118-25.

15. Gelisse P, Genton P, Raybaud C, Thiry A, Pincemaille O. Benign childhood epilepsy with centrotemporal spikes and hippocampal atrophy. Epilepsia 1999; 40: 131-25.

16. Piccirili M, Dálexandro P, Tiacci C, Ferroni A. Language lateralization in children with benign partial epilepsy. Epilepsia 1988; 29: 19-25.

17. Herranz JL. Amplio espectro clínico y pronóstico de las epilepsias rolándicas: acuerdos desacuerdos y cuestiones abiertas. Rev Neurol 2002; 35(1): 79-81.

18. Fejerman N. Evoluciones atípicas de las epilepsias parciales benignas en los niños. Rev Neurol 1996; 24(135): 1415-20.

19. Prats J, Rua MJ, Mandoz P. Epilepsia benigna infantil con paroxismos rolándicos. Su historia natural y sus límites. Anuario Neurología Evolutiva. Guipúzcoa: Aspace; 1983, p. 123-5.

20. Reagan MOE, Braun JK, Goodwin GM, Clarke M. Epileptic Aphasia: A consecuence of regional Hypometabolic Encephalopathy? Developmental Medicine and Child Neurology 1998; 40: 508-16.

21. Weglage J, Demsky A, Pietsch M, Kurlemmann G. Neuropsychological, intelectual, and behavioral findings in patient with centro-temporal spikes with and without Seizures. Dev Med Child Neurol 1997; 39: 646-51.

22. Doose H, Brigger-Heber B, Neubauer B. Children with focal sharp waves: clinical and genetic aspects. Epilepsia 1997; 28: 788-96.

23. Prita D, Persico I, Serra D, De Montis N, Congil R, Loi M. Lack of association with the 15q14 candidate region for benign epilepsy of childhood with centro-temporal spike in a Sardinian population. Epilepsia 2000; 41(Suppl. Florence): 164 (abstract).

24. Scheffer JE, Jones L, Pozzebon M, Howell RA, Saling MM, Ver Kovic SF. Autosomal dominant rolandic epilepsy and speech dyspraxia: A new syndrome with anticipation. Ann Neurol 1995; 28: 4622-42.

25. Scheffer IE, Jones L, Pozzebos M. Autosomal dominant rolandic epilepsy and speech dyspraxia: A new syndrome with anticipation. Ann Neurol 1995; 38: 633-42.

26. Arcos BM, Palacio LG, Sánchez JL, Jiménez ME, Mora D, Zuluaga L, et al. Anticipación genética en epilepsia idiopática. Rev Neurol 1999; 29(7): 597-9.

27. Beavmanoir A, Ballis T, Burfis D, Ausari K. Benign epilepsy of childhood with rolandic spikes. A clinical, electroencephalografic and telecephalographic study. Epilepsia 1974; 16: 301-15.

28. Patry G, Lyagouby S, Tassinari CA. Subclinical Electrical Status Epilepticus induced by sleep in children. Arch Neurol 1971; 24: 242-52.

29. Aicardi J, Chevrie JJ. Atypical benign epilepsy of childhood epilepsy. Arch Neurol 1982; 24: 281-92.

30. Deonna T, Ziegler AL, Despland PA. Combined myoclonic astatic and benign focal epilepsy of childhood (Atypical benign partial epilepsy of childhood). A separate syndrome? Neuropediatrics 1986; 17: 144-51.

31. Markland ON. Slow spike-wave activity in EEG and associated clinical features: Often called Lennox or Lennox- Gastaut syndrome. Neurology 1977; 27: 746-57.

32. Peter JM, Camfield CS, Camfield PR. Population study of bening rolandic epilepsy: Is treatment need? Neurology 2001; 57: 537-9.

33. Massa R, Saint-Martin de A, Carcangiu R, Rudolf G, Seegmuller C, Kleitz C, et al. EEG criteria predictive of complicated evolution in idiopathic rolandic epilepsy. Neurology 2001; 37: 1071-9.

34. Arroocelo G, Giovatarci-Rosi P, Tassittari TA. Predictive factor of seizure frecuency and titratin of antiepileptic treatment in rolandic epilepsy. A retrospective study. Brain Dev 1987; 9: 300-4.

35. Bouma PA, Boverkerk AC, Westercorp RG, Brolwer OF. The course of bening partial epilepsy of childhood with centro-temporal spikes. A metaanalysis. Neurology 1997; 48: 430-7.