2012, Number 2
Use of hematological parameters for antiretroviral treatment in a group of patients with HIV/AIDS
Language: Spanish
References: 19
Page:
PDF size: 136.15 Kb.
ABSTRACT
A transversal study of 574 adult Angolan patients with the HIV/AIDS infectiondisease was performed during the period from July 2001 to July 2005, cared in external consultation at Luanda's multi-profile surgical clinic, in order to determine if some humoral laboratory parameters are useful to allow the control of antiretroviral treatment. Patients were divided into two subgroups according to the count of lymphocytes CD4+. it was analyzed the association of this with the total count of lymphocytes, hemoglobin levels and erythrocyte sedimentation rate, and assessing the performance of these hematological indicators, sensitivity, specificity and predictive values. The total lymphocyte count, hemoglobin levels and erythrocyte, are useful parameters for monitoring Highly Active Antiretroviral Therapy in patients with HIV/AIDS in low-income countries, because they have a significant relationship with established variables of immune deficiency, high specificity and positive predictive value.REFERENCES
Friedman-Kien A, Laubenstein L, Marmor M, Hymes K, Green J. Kaposi’s sarcoma and pneumocystis pneumonia among homosexual men - New York City and California. Morb Mortal Wkly Rep [Internet]. 1981 Jul [cited 2011 Jun 16];30. Disponible en: http://www.cdc.gov/hiv/resources/reports/mmwr/pdf/mmwr04jul81.pdf
WHO, HIV/AIDS, Department Family and Community Health Cluster. Scalling up antiretroviral therapy in resource-limited setting: guide for a public health approach. Ginebra. OMS [Internet]. 2002 Jun [cited 2011 Jun 16]. Disponible en: http://data.unaids.org/publications/IRC-pub01/jc354- scalingupguidelinesdoc_en.pdf
Mekonen Y, Dukers NH, Sander E, Wendeliena D, Dawita W, Schaap A [et al]. Simple markers for initiating antiretroviral therapy among HIV-infected Ethiopians. AIDS [Internet]. 2003 [cited 2011 Jun 16];17(6). Disponible en: http://journals.lww.com/aidsonline/Abstract/2003/04110/Simple_markers_for _initiating_antiretroviral.6.aspx
Rodriguez WR, Christodoulides N, Floriano PN, Graham S, Mohanty S, Dixon M [et al]. A microchip CD4 counting method for HIV monitoring in resource-poor settings. Plos Medicine [Internet]. 2005 Jul [cited 2011 Jun 16]. Disponible en: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pme d.0020182
Van der Ryst E, Kotze M, Joubert G, Steyn M, Pieters H, van der Westhuizen M [et al]. Correlation among total lymphocyte count, absolute CD4+ count and CD4+ percentage in a group of HIV-1-infected South African patients. J Acquir Immune Defic Syndr Hum Retrovirol [Internet]. 1998 Nov [cited 2011 Jun 16];19(3). Disponible en: http://journals.lww.com/jaids/fulltext/1998/11010/correlation_among_total_ly mphocyte_count,_absolute.5.aspx
Akinola NO, Olasode O, Adedirau IA, Onayemi O, Murainah A, Irinoye O [et al]. The search for a predictor of CD4 cell count continues: total lymphocyte count is not a substitute for CD4 cell count in the management of HIV infected individual in a resource- limited setting. Clin Infect Dis [Internet]. 2004 [cited 2011 Jun 16];39. Disponible en: http://cid.oxfordjournals.org/content/39/4/579.full.pdf
Spacek LA, Griswold M, Quinn TC, Moore RD. Total lymphocyte count is a useful tool for the timing of opportunistic infection prophylaxis in India and other resource-constrained countries. J Acquir Immune Defic Synd [Internet]. 2003 Jun [cited 2011 Jun 16];31(4). Disponible en: http://journals.lww.com/aidsonline/Fulltext/2003/06130/Increasing_rates_of_ malarial_fever_with.5.aspx
Angelo AL, Angelo CD, Torres AJ, Costa Ramos AM, Lima M, Martins NE [et al]. Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients. Braz J Infect Dis [Internet]. 2007 Oct [cited 2011 Jun 16];11(5). Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413867020070005 00005
García VE, Gárgolas M y Fernandez Guerrero ML. Relación entre velocidad de sedimentación globular, situación clínica e inmunitaria, y carga viral en pacientes infectados por el VIH no hospitalizados. Rev Esp de Quimioterapia [Internet]. 2001 Sept [citado 27 Jul 2007];14(3). Disponible en: http://www.seq.es/seq/html/revista_seq/0301/or2.html
Piedras RJ, Barrales BO, Reyes LAR, López Karpovitch X. Diferencia en la interpretación diagnóstica de la velocidad de sedimentación globular entre los métodos de Wintrobe y Westergren automatizado. Lab Acta [Internet]. 2003 [citado 27 Jul 2007];15(1). Disponible en: http://www.imbiomed.com.mx/1/1/articulos.php?method=showDetail&id_revi sta=3&id_seccion=13&id_ejemplar=1359&id_articulo=13250