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2013, Number 3

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Med Crit 2013; 27 (3)

Thiamine administration in critically ill patients to optimize carbohydrate metabolism and decrease insulin requirements

Herrera PJE , Fonseca LJA, Hernández CCM

Language: Spanish
References: 17
Page: 132-137
PDF size: 190.08 Kb.


ABSTRACT

Objective: To show that thiamine supplementation in critically ill patients optimizing the metabolism of carbohydrates and reduces insulin requirements.
Design: Clinical Study, Prospective, Longitudinal.
Sitting: The Intensive Care Unit of the Instituto Nacional de Ciencias Médicas y Nutrición «Salvador Zubirán».
Patients: Admitted in Intensive Care Unit during their first 24 hours of stay.
Interventions: Doses of thiamine 300 mg for the first three days of stay.
Measurements and principal results: Daily, it was registered: levels of glucose in blood, lactate and in insulin requirements. Relative risks were estimated with respect to the possibility of present or not at least one event of hyperglycemia RR 0.46 (0.059, 0.580), p 0.016. It was observed a protector of factor to 50% when thiamine was used we could deduce that thiamine administration reduces the risk to have episodes of hyperglycemia. There isn’t significant difference in the levels of lactate, daily insulin requirement, or the number of events in each group, condition, mainly to the dispersion of the results.
Conclusions: Given the dispersion obtained in the population, and the results obtained in the analysis of relative risk it would be worth to increase the number of sample given that tendency to decrease episodes of hyperglycemia in patients that were treated with thiamine.


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