medigraphic.com
ISSN 1727-897X (Electronic)

2013, Number 3

<< Back Next >>

Medisur 2013; 11 (3)

Hemolytic Uremic Syndrome Associated with Pneumococcal Pneumonia. A Case Report

Uriarte MAE, Prieto AA, Vila DJ, Capote PJL, Villavicencio CK,Fernández GA

Language: Spanish
References: 20
Page: 296-301
PDF size: 228.97 Kb.


ABSTRACT

Hemolytic uremic syndrome is a condition characterized by hemolytic microangiopathic anemia, thrombocytopenia and acute renal failure. In its classic form it is associated with diarrhea and it has a good prognosis. When there is an invasive pneumococcal disease as underlying condition, it has a mortality rate of 25%, and half of the surviving cases develop end-stage renal disease (ESRD). We present the case of a 17-month-old child with hemolytic uremic syndrome secondary to pneumonia with empyema, who after being anuric and in intensive peritoneal dialysis for 10 days achieved normal renal function. His successful treatment, along with the fact that there are no similar cases published in our province, encouraged us to carry out this work.


REFERENCES

  1. Rodríguez de Córdoba S, Montes T. Síndrome hemolítico urémico atípico. Nefrología Sup Ext. 2011 ; 2 (1): 58-65.

  2. Bender JM, Ampofo K, Byington CL, Grinsell M, Korgenski K, Daly JA, et al. Epidemiology of Streptococcus pneumoniae–induced hemolytic uremicsyndrome in Utah children. Pediatr Infect Dis J. 2010 ; 29 (8): 712-6.

  3. Clark WF, Sontrop JM, Macnab JJ, Salvadori M, Moist L, Suri R, et al. Long term risk for hypertension, renal impairment, and cardiovasculardisease after gastroenteritis from drinking water contaminated with Escherichia coli O157:H7: a prospective cohortstudy. BMJ. 2010 ; 341: c6020.

  4. Copelovitch L, Kaplan BS. Streptococcus pneumoniae–associated hemolytic uremic syndrome. PediatrNephrol. 2008 ; 23 (11): 1951-6.

  5. Piercefield EW, Bradley KK, Coffman RL, Mallonee SM. Hemolytic uremic syndrome after an Escherichia coli O111outbreak. Arch Intern Med. 2010 ; 170 (18): 1656-63.

  6. Fàbregas Martori A, Moraga Llop F, Nieto Rey J, Figueras Nadal C, Soler Palacín P, Roqueta Mas J. Enfermedad neumocócica invasiva y síndrome hemolítico urémico. An Pediatr (Barc). 2008 ; 68 (3): 269-72.

  7. Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. N Engl J Med. 2009 ; 361 (17): 1676-87.

  8. Copelovitch L, Kaplan BS. Streptococcus pneumoniae-associated hemolytic uremic síndrome: classification and the emergence of serotype 19A. Pediatrics. 2010 ; 125 (1): e174-82.

  9. Banerjee R, Hersh A, Newland J, Beekmann S, Polgreen P, Bender J, et al. Streptococcus pneumoniae associated Hemolytic Uremic Syndrome Among Children in North America. Pediatr Infect Dis J. 2011 ; 30 (9): 736-9.

  10. Brote de Síndrome Urémico Hemolítico en Alemania Por Escherichia coli enterohemorrágica productora de toxina Shiga, cepa O104:H4 [Internet]. Caracas: Red de Sociedades Científicas Médicas Venezolanas; 2011. [cited 30 Oct 2013] Available from: http://www.rscmv.org.ve/pdf/nota_tecnica40.pdf.

  11. Nyman AG, Pitchumani S, Jaffe A, Sonnappa S. Pneumococcal empiema and haemolytic uraemic syndrome in children: experience from a UK tertiary respiratory centre. Arch Dis Child. 2009 ; 94 (8): 645-6.

  12. Goicoechea de Jorge E, Harris CL, Esparza Gordillo J, Carreras L, Arranz EA, Garrido CA, et al. Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome. Proc Natl Acad Sci USA. 2007 ; 104 (1): 240-5.

  13. Frémeaux Bacchi V, Miller EC, Liszewski MK, Strain L, Blouin J, Brown AL, et al. Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood . 2008 ; 112 (13): 4948-52.

  14. Rodríguez de Córdoba S, Goicoechea de Jorge E. Translational mini-review series on complement factor H: genetics and disease associations of human complement factor. H. Clin Exp Immunol. 2008 ; 151 (1): 1-13.

  15. Ariceta G, Besbas N, Jonson R, Karpman D, Landau D, Licht C, et al. Guideline for the investigation and inicial therapy of diarrea-negative hemolytic uremia síndrome. Pediatr Nephrol. 2009 ; 248 (4): 687-96.

  16. Hirt Minkowski P, Dickenmann M, Schifferli J. Atypical Hemolytic Uremic Syndrome: Update on the Complement System and What is new. Nephron Clin Pract. 2010 ; 114 (4): c219-35.

  17. Waters AM, Licht C. aHUS caused by complement dysregulation: New therapies on the horizon. Pediatr Nephrol. 2011 ; 26 (1): 41-57.

  18. Loirat C, Noris M, Fremeaux Bacchi V. Complement and the atypical hemolytic uremic syndrome in children. Pediatr Nephrol. 2008 ; 23 (11): 1957-72.

  19. Crookston KP, Reiner AP, Cooper LJN, Sacher RA, Blajchman MA, Heddle NM. RBC T activation and hemolysis: implicationsfor pediatric transfusion management. Transfusion. 2000 ; 40 (7): 801-12.

  20. Van Why SK, Avner ED. Hemolytic-Uremic Syndrome. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE, editors. Nelson Textbook of Pediatrics. 19th. ed. Philadelphia: Saunders; 2011. p. 2281-84.




2020     |     www.medigraphic.com