2013, Number 1
<< Back Next >>
Mediciego 2013; 19 (1)
Which is the actual role of digoxin in the time of the multicentric studies?
Sevilla PB, Camacho AVJ, de la Nuez RE
Language: Spanish
References: 26
Page:
PDF size: 40.33 Kb.
ABSTRACT
Digoxin has been for more than 200 years one of the fundamental pillars in the treatment of
heart failure and an ample and accumulated experience exist with its use in the clinical
practice. For more than 2 decades, an increasing tendency exists to diminish the utility and
indications of this medicine, which it does not represent special economic interest for any firm
or pharmaceutical companies, that finance in last resort, support or promote the
accomplishment of the great multicentric studies and clinical tests that dictate the guidelines of
treatment in cardiology and present medicine.In the present work, It stands out the
importance and actual instruction of this medicine, that maintains its utility and validity, in the
era of great multicentric studies and clinical tests.
REFERENCES
McMurray J, Petrie M, Murdoch D. Clinical epidemiology of heart failure: public and private health burden. Eur Heart J. 1998; 19(Suppl P):9-16.
Hunt S, Backer D, Chin M, Cinquegrani M, Feldman A, Francis G, et al. ACC/AHA Guidelines for the evaluation and management of chronic heart failure in the adult. J Am Coll Cardiol. 2001; 38:2101-13.
Rodríguez-Artalejo F, BanegasBanegas JR, Guallar-Castillón P. Epidemiología de la insuficiencia cardíaca. Rev Esp Cardiol. 2004; 57:163-70.
McMurray JJ, Stewart S. Epidemiology, aetiology, and prognosis of heart failure. Heart. 2000; 83:596-602.
Rose E, Gelinjns A, Moskowitz A. Randomized evaluation of mechanical assistance for the treatment of congestive heart failure (REMATCH) study group. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med. 2001; 345: 1435-43.
McCullough PA, Philbin EF, Spertus JA, Kaatz S, Sandberg KR, Weaver WD. Confirmation of a heart failure epidemic: findings from the Resource Utilization Among Congestive Heart Failure (REACH) study. J Am CollCardiol. 2002; 39:60-9.
MacIntyre K, Capewell S, Stewart S, Chalmers JWT, Boyd J, Finlayson A, et al. Evidence of improving prognosis in heart failure. Trends in case fatality I 66547 patients hospitalized between 1986 and 1995. Circulation. 2002; 102:1126-31.
Rodríguez Artalejo F, Guallar Castillón P, Banegas Banegas JR, del Rey Calero J. Trends in hospitalization and mortality for heart failure in Spain, 1980-1993. Eur Heart J. 1997; 18:1771-9.
Clelaand JGF, Khand A, Clark A. The heart failure epidemic: exactly how big is it? Eur Heart J. 2001; 2: 623-626.
Anguita Sánchez M, Vallés Bel F. ¿Quién debe tratar la insuficiencia cardíaca? Rev Esp Cardiol. 2001; 54:815-8.
Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, Komajda M, et al. Guías de práctica clínica sobre el diagnóstico y tratamiento de la insuficiencia cardíaca crónica. Versión resumida (actualización 2005). Rev Esp Cardiol. 2005; 58(9):1062-92.
Giverts M, Colucci W, Braunwald E. Clinical aspects of heart failure; pulmonary edema, high-output failure, En: Zipes D, Libby P, Bonow R, Braunwald E, editors. Braunwald's heart disease. A textbook of cardiovascular medicine. 7th ed. Philadelphia: Elsevier Saunders; 2005. p. 539-68.
Cleland JG, Swedberg K, Follath F, Komajda M, Cohen-Solal A, Aguilar JC, et al. The Euro Heart Failure survey programme: a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. Eur Heart J. 2003; 24:442-63.
Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. ACC/AHA 2005 Guideline Update for the diagnosis and management of chronic heart failure in the adult summary article. Circulation. 2005; 112:1825-52.
Gibson DG, Francis DP. Clinical assessment of left ventricular diastolic function. Heart. 2003; 89:231-8.
Oh JK, Hatle L, Tajik AJ, Little WC. Diastolic heart failure can be diagnosed by comprehensive two-dimensional and Doppler echocardiography. J Am Coll Cardiol. 2006; 47:500-6.
Senni M, Tribouilly CM, Rodeheffer RJ, Jacobsen SJ, Evans JM, Bailey KR, et al. Congestive heart failure in the community. A study of all incident cases in Olmsted County, Minnesota, in 1991. Circulation. 1998; 98:282-9.
Vasan RS, Larson MG, Benjamin EJ, Evans JC, Reiss CK, Levy D. Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction. Prevalence and mortality in a population-based cohort. J Am Coll Cardiol. 1999; 33:1948-55.
García Castelao A, Muñiz J, Sesma P, Castro-Beiras A. Utilización de recursos diagnósticos u terapéuticos en pacientes ingresados por insuficiencia cardiaca: influencia del servicio de ingreso (estudio INCARGAL). Rev Esp Cardiol. 2003; 6:49-56.
González Juanatey JR, Mazón P, Varela A. Insuficiencia cardiaca con función sistólica conservada (insuficiencia cardiaca diastólica). En: Anguita M, editor. Manual de insuficiencia cardiaca. Madrid: Sociedad Española de Cardiología; 2003. p. 91-110.
Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure. Part II. Causal mechanisms and treatment. Circulation. 2002; 105:1503-8.
Hamlin NP, Willerson JT, Garan H, Powell WP. The neurogenic vasoconstrictor effect of digitalis on coronary vascular resistance. J Clin Invest. 1974; 53:288-96.
Nohria A, Lewis E, Stevenson LW. Medical management of advanced heart failure. JAMA. 2002; 287:628-40.
Uretsky BF, Young JB, Shahidi FE, Yellen LG, Harrison MC, Jolly MK, et al. On behalf of the PROVED Investigators Group. Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED trial. J Am Coll Cardiol. 1993; 22: 955-962.
Packer M, Gheorghiade M, Young JB, Constantini PJ, Adams KF, Cody RJ, et al; Radiance Study. Withdraval of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors. N Engl J Med. 1993; 329: 1-7.
The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med. 1997; 336: 525-533.