Garzón-Sánchez E, Reyes HKL, Reyes HDP, López CG, Hernández PM, Reyes HU, Reyes GU

Language: Spanish
References: 23
Page: 137-144
PDF size: 463.92 Kb.

ABSTRACT

Objective: To assess the effectiveness of the intramuscular gammaglobulin in pharyngeal herpes. Material and method: Prospective, observational and descriptive study in pediatric patients, from June 31 of 2000 to may 31 of 2010, in a private hospital. We included patients with compatible clinical presentation, and without topic treatment or antiviral treatment previously. We excluded the patients who received the vaccine in their habitual scheme, 4 weeks after, and in the cases the parents did not accept the treatment. The dosage of gammaglobulin was a 0.02-0.03 mL/kg intramuscular, single dose. The patients were in observation looking for secundary reactions. For the statistical evaluation we used the Spearman´s rank correlation coefficient and the coefficient of determination R2.
Results: We analyzed 87 patients: 68 infants, 15 children from 3 to 5 years and 4 older children. The duration of the clinical findings was less than 48 hours in 43 patients, 2 to 5 days in 35 patients and more than 5 days in 9 patients. 71 patients (81.6%) had a favorable resolution in less than 48 hours; 7 patients (8%) had a good response in 96 hours and 9 patients (10.3%) had no response. Secondary reaction to gammaglobulin was observed in one case. The correlation coefficient (Spearman Rho) between the variables: application of gammaglobulin and shortening of the clinical manifestation showed a value of 0.732. It was statistically significant with p‹0.001 and an R square of 0.774.
Conclusions: The intramuscular gammaglobulin was a coadyuvant treatment in pharyngeal herpes with good response in 89% of patients, according to this study. For definitive conclusions a larger group is required and to compare it without gammaglobulin or with antiviral therapy.

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