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2012, Number 4

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Rev Hosp Jua Mex 2012; 79 (4)

Susceptibilidad al desarrollo de cáncer de mama: detección del polimorfismo XbaI

Álvarez-Librado CA, Quinto-Villalobos JE, García-López ES, Cortés-Malagón EM, Bonilla-Delgado J, Jiménez-Villanueva X, Chávez-Ocaña S, García-Jiménez E, Sierra-Martínez M, Acosta-Altamirano G, Reyes-Hernández OD

Language: Spanish
References: 16
Page: 225-228
PDF size: 144.74 Kb.


ABSTRACT

Introduction. Breast cancer is a priority health in Mexico. This cancer is regulated by hormones as estrogens. ERa is a ligand dependent receptor involved on estrogen disposition. ESR1, codifying gen of ERa, contains the SNP XbaI, this polymorphism has been asociated to breast cancer development. The XbaI frequency has been poor studied in Mexican population. Objective. Determine the XbaI frequency by Real-Time PCR, in a female health group and another female group having breast cancer from Hospital Juárez de México (HJM). Material and methods. XbaI was evaluated by Real-Time PCR in 26 health women and 27 breast cancer patients. Results. In accordance with statistic analysis (χ2) a significative difference has not found among both groups (p > 0.05), by the other hand a significative difference has observed in comparison with European population (p < 0.05). Conclusions. This study has been the first attempt to identify this polymorphism in HJM patients and the increase of participants may contribute to obtain a more representative frequency according to HJM Mexican population.


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