2013, Number 1
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Patol Rev Latinoam 2013; 51 (1)
Notes on the history of leukemia
Ortiz-Hidalgo C
Language: Spanish
References: 39
Page: 58-69
PDF size: 449.21 Kb.
ABSTRACT
The First published description of a case of leukemia was present
by Velpeau in 1827. Eleven years after, Donné described a patient
with an excess of white blood cells, and in 1845 a patient with an
enlarged spleen in which death took place from the presence of
purulent matter in the blood, was reported by J.H Bennett. The
term leukemia was coined by Virchow in 1856. Further advances
in the understanding of leukemia occurred rapidly thereafter by
several scientists like Ehrlich, who developed a technique of staining
cells, Neumann, who recognized that the blood cells were made in
the bone marrow, an Norwell and Hungerford who described the
Philadelphia Chromosome in patients with chronic myelogenous
leukemia. In 1947 the pathologist Sidney Farber acquired folic
acid antagonists, that were available to him by the biochemist
Subbarow, and administered to children with leukemia observing
temporary remission. Today, scientific progress like the successful
therapeutic application of imatinib in patient with certain forms of
leukemia, has provided a proof of target therapy in patients with
various types of cancer.
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