2009, Number 1
<< Back Next >>
Rev Hosp Jua Mex 2009; 76 (1)
Determinación temprana de sepsis mediante la prueba clínica de procalcitonina en pacientes pediátricos
Torres AMA, Olvera LG, Castorena VI
Language: Spanish
References: 13
Page: 4-9
PDF size: 196.31 Kb.
ABSTRACT
Introduction. The sepsis is a condition that occurs with multiple clinical manifestations which are common to various pathologies,
making it necessary to have a diagnostic test for early identification of sepsis and thus initiate early treatment to reduce morbidity
and mortality of this pathology.
Objective. To determine serum procalcitonin in pediatric patients with sepsis or suspected sepsis.
Material and methods. Prospective, longitudinal study, diagnostic test. We included patients diagnosed with sepsis according to
the definition of the last conference of international consensus for pediatric sepsis 2005. The patients included were carried out
measuring serum procalcitonin at the time of diagnosis of sepsis.
Results. A total of 30 patients, 14 female and 16 male were
included. The breakdown by age group was as follows: six patients younger than 1 year, five of 1 2 years, six of 2 to 5 years, three
of 6 to 12 years and ten over 12 years. We found a sensitivity of 70% with a specificity of 45%.
Discussion. Measuring serum
procalcitonin in pediatric patients with suspected sepsis is a useful tool for diagnosing bacterial sepsis, thus justifying the initiation
of antibiotic therapy before a result of abnormal procalcitonin.
REFERENCES
Assicot M, Bohuon C, Gendrel D, Raymond J, Carsin H, Guilbaud J. High serum procalcitonin concentrations in patients with sepsis and infection. The Lancet 1993; 341(8844): 515-8.
Weglöhner W, Struck J, Fischer-Schulz C, Morgenthaler NG, Otto A, Bohuon C, Bergmann A. Isolation and characterization of serum procalcitonin from patients with sepsis. Peptides 2001; 22(12): 2099-103.
Müller B, White JC, Nylen ES, Snider RH, Becker KL, Habener JF. Ubiquitous expression of the calcitonin-I gene in multiple tissues in response to sepsis. J Clin Endocrin & Metab 2001; 86: 396-404.
De Werra I, Jaccard C, Coorradin SB, et al. Cytokines, nitrite/ nitrate, soluble tumor necrosis factor receptors and procalcitonin concentrations: comparison in patients with septic shock. Critical Care Medicine 1997; 25(4): 607-13.
Becker KL, O’Neil WL, Spider R, Nylen E, Moore CF, Jeng J, et al. Hypercalcitoninemia in inhalation burn injury: a response of the pulmonary neuroendocrine cell. Anat Rec 1993; 236: 136-8.
Gendrel D, Reymond J, Coste J, Moulin F, Lorrot M, Guerin S, et al. Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections. Pediatr Infec Dis J 1999; 18: 871-81.
Becker KL, Snider R, Nylen ES. Procalcitonin assay in systemic inflammation, infection, and sepsis: Clinical utility and limitations. Crit Care Med 2008; 36(3): 941-52.
Angus D, Burgner D, Wunderink R, Mira JP, Gariach H, Wiederman CJ, Vicent JL. Meeting report. The PIRO concept: Critical Care Forum 2003; 7: 348-51.
Ugarte H, Silva E, Marcan D, et al. Procalcitonin use as a marker of infection in the intensive care unit. Crit Care Med 1999; 27: 498-504.
Ruokone E, Ilkka I, Niskanen M, Takala J. Procalcitonin and neopterin as indicators of infection in critical ill patients. Acta Anaesthesiol Scand 2000; 45: 398-404.
Selberg O, Hecker H, Martin M, Klos A, Bautsch W, Konhi J. Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin 6. Crit Care Med 2000; 28: 2793-8.
Hartbarth S, Holeckova K, et al. Diagnostic Value of procalcitonin, interleukin 6, and interleukin 8 in critical ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 2001; 164: 396-402.
Tugrul S, Esen F, Celebi S, et al. Reliability of procalcitonin as a severity marker in critical ill patients with inflammatory response. Anaesth Intensive Care 2002; 30: 747-54.