2013, Number 2
<< Back Next >>
Med Cutan Iber Lat Am 2013; 41 (2)
Vulvar melanoma. An unusual location
Feinsilber D, Acosta AC, Schroh R, Lemme JL, Rosati OM, Corbella C, Kogan N, Festa H
Language: Spanish
References: 22
Page: 49-54
PDF size: 396.74 Kb.
ABSTRACT
Melanoma is the second most common invasive cancer of the vulva, with a poor prognosis, a tendency for local recurrence and survival between 16 to 50%.
Methods:We present 7 patients with vulvar melanoma seen at the Dermatology Sector of Oncology, Hospital Ramos Mejía in the course of 17 years,
we evaluate and compare their characteristics with the international literature.
Results: The incidence in our population was 1.3% with an average age of 61 years, similar to the literature. Of these 7 melanomas, 72% originated
on normal skin and preexisting nevi 28%, 61% and 39% respectively for the world literature. These melanomas were located mainly on labia majora
(72%), while those in the literature were in the periclitoidea area (30%). In our patients the most common were Superficial Spreading Melanoma
(57%) and in literature Mucosal Lentiginous Melanoma (43-57%). The prognosis is poor in both reviews, with a 5-year survival of 28% in our patients
and 27-59% in the literature. For treatment, the current trend is to perform a less radical and more individualized.
Conclusions: The features of vulvar melanoma indicate that their behavior does not differ significantly from cutaneous melanoma, although its late
diagnosis leads to a worse prognosis.
REFERENCES
Medina-Villaseñor EA, Hernández-Aten D, Román-Bassaure E, Torres-Lobatón A. Melanoma de vulva, revisión de los factores pronóstico. A propósito de un caso. Ginecología Oncol 2007; 6: 134-9.
Raspagliesi F, Ditto A, Paladini D, Fontanelli R, Stefanon B, DiPalma S, De Palo G. Prognostic Indicators in Melanoma of the Vulva. An oSurg Oncol 2007; 7: 738- 42.
Sugiyama VE, Chan JK, Shin JY, Berek JS, Osann K, Kapp D. Vulvar melanoma. A multivariable analysis of 644 patients. Obstetrics Gynecol 2007; 110: 296-301.
Gutiérrez MP, Marengo M, Mainardi C, Valente E, Ruiz Lascano A. Melanoma de Vulva. Reporte de un caso. Dermatol Argent 2008; 14: 134-6.
Gatti CF, Cha DM, Barquin MA, Giongrande JC, Prhal P. Melanoma vulvo vaginal. Reporte de un caso. Dermatol Argent 1996; 2: 230-3.
Gutiérrez MP, Barengo MA, Sureda N et al. Melanoma. Variantes inusuales. Arch Argent Dermatol 2007; 57: 89-93.
Sanz MI, Feinsilber D, Corbella C, Schroh R, Hassan ML. Tumores raros de difícil diagnóstico inicial. Dermatol Argent 2009; 15: 272-7.
Alasino M, García Llaver V, Parra V, Aredes Ángeles, Jiménez C, Innocenti C, Daguerre P. Tumores no espinocelulares de vulva. Incidencia en ocho años. Dermatol Argent 2011; 17: 277-83.
Ragnarsson-Olding BK, Kanter-Lewensohn LR, Langerlöf B, Nilsson BR, Ringborg UK. Malignant melanoma of the vulva in a Nationwide, 25-year study of 219 Swedish females. Clinical observations and histopathologic features. Cancer 1999; 86: 1273-84.
Ragnarsson-Olding BK, Nilsson BR, Kanter- Lewensohn LR, Langerlöf B, Ringborg UK. Malignant melanoma of the vulva in a Nationwide, 25-year study of 219 Swedish females. Predictors of survival. Cancer 1999; 86: 1285-93.
Räber G, Mempel V, Jackisch C, Hundeiker M, Heinecke A, Kürzl R et al. Malignant melanoma of the vulva: report of 89 patients. Cancer 1996; 78: 2353-58.
Hopkins MP, Neumunaitis-Keller J. Carcinoma of the vulva. Obstetrics Gynecol Clinics North Am 2001; 28: 791-804.
De Simone P, Silipo V, Pierluigi B, Mariani G, Marenda S, Eibenschutz L et al. Melanoma Res 2008; 18: 127-33.
Balch C, Gershenwald J, Soong S, Thompson J, Atkins M, Byrd D et al. Final Version of 2009 AJCC Melanoma Staging and Classification. J Clin Oncol 2009; 27: 6199-206.
Consenso Nacional Inter-Sociedades sobre Melanoma Cutáneo. Academia Nacional de Medicina. Junio de 2011.
Moxley KM, Fader AN, Rose PG, Case AS, Ruth DG, Berry E et al. Malignant melanoma of the vulva: An extension of cutaneous melanoma? Gynecol Oncol 2011; 122: 612-7.
Arica D, Sánchez J, Álvarez M, Alarcón E. Melanoma maligno de vulva en el Instituto Nacional de Enfermedades Neoplásicas: experiencia de 50 años. Folia Dermatol Perú 2007; 18: 118-23.
Hullu J, Hollema H, Hoekstra H, Piers DA, Mourits MJ, Aalders JG, van der Zee AG. Vulvar melanoma. Is there a role for sentinel lymph node biopsy? Cancer 2002; 94: 486- 91.
Nasu K, Kai Y, Ohishi M, Kato A, Sato H, Fujiwara S et al. Conservative surgical treatment for early-stage vulvar malignant melanoma. Arch Gynecol Obstet 2010; 281: 335-8.
Levenback C, Coleman R, Burke T, Bodurka-Bevers D, Wolf J, Gershenson D. Intraoperative lymphatic mapping and sentinel node identification with blue dye in patients with vulvar cancer. Gynecol Oncol 2001; 83: 276-81.
Phillips GL, Bundy BN, Okagaki T, Kucera PR, Stehman FB. Malignant melanoma of the vulva treated by radical hemivulvectomy: a prospective study of the Gynecologic Oncology Group. Cancer 1994; 73: 2626-32.
Irvin WP, Legallo RL, Stoler MH, Rice LW, Taylon PT, Andersen WA. Vulvar Melanoma: A Retrospective Analysis and Literature Review. Gynecol Oncol 2001; 83: 457-65.