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2011, Number 3

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Med Sur 2011; 18 (3)

Usefulness of diffusion-perfusion analysis by magnetic resonance imaging for ischemic penumbra detection in brain stroke

Martínez-Martínez LÁ, Roldán-Valadez E, Fernández LY, Corona-Cedillo R, Martínez-López M

Language: English
References: 29
Page: 139-147
PDF size: 535.09 Kb.


ABSTRACT

Stroke is the leading cause of mortality and morbidity in the developed world. Current technological advancement allows not only a depiction of the infarcted tissue, but also of the adjacent tissue with oligemia, i.e., the region of penumbra. We consider that magnetic resonance (MR) imaging is the best method for the study and assessment of brain stroke and penumbra. Conventional imaging is currently only a complement to the diffusion-perfusion analysis that allows us to quantify cerebral blood flow and volume (CBF and CBV), as well as the time-to-peak (TTP) following the administration of contrast material. These three parameters constitute the hemodynamic variables that are altered in a brain stroke. In this paper we present the typical MR findings in the clinical case of a patient with hyperacute brain stroke, showing blood flow loss from the left middle cerebral artery, an important area of penumbra; ADC decrease from 40 to 70%; CBF and CBV decrease; MTT increase, and TTP with a delay of 10 to 13 s.


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