2010, Number 1
<< Back Next >>
Med Sur 2010; 17 (1)
Encefalopatía hiperamonémica asociada a ácido valproico. Reporte de caso y revisión de la literatura
Aguilar-Zapata DA, Aguilar ON, de la Torre SMC, Herrera-García JC, Cacho DB, González-Chon O
Language: Spanish
References: 11
Page: 22-24
PDF size: 92.09 Kb.
ABSTRACT
Valproic acid is a widely known anticonvulsive drug for its use in the
epilepsy treatment. One of its rare adverse reactions is the hyperamonemic
encephalopathy which is characterized by a severe encephalopathy.
This is a case report of a 36 year old woman with history
of difficult control epilepsy. After changing her usual treatment to
valproic acid she developed encephalopathy, with normal liver function
test, with secondary hyperamonemia with a good respond to iv
L-ornitin/L-aspartat and oral L-carnitine treatment.
REFERENCES
Wadzinski J, Franks R, Roane D, Bayard M. Valproate-associated Hyperammonemic Encephalopathy. J Am Board Fam Med 2007; 20: 499-502.
Johannessen CU, Johannessen SI. Valproate: past, present, and future. CNS Drug Rev 2003; 9: 199-216.
Gidal BE, Inglese CM, Meyer JF, et al. Diet- and valproateinduced transient hyperammonemia: effect of L-carnitine. Pediatr Neurol 1997; 16: 301.
Duarte J, Macias S, Coria F, Fernandez E, Claveria LE. Valproate- induced coma; case report and literature review. Ann Pharmacother 1993; 27: 582-83.
Blindauer KA, Harrington G, Morris GL, et al. Fulminant progresion of demyelinating disease alter valproate induced encephalopathy. Neurology 1998; 51: 292-5.
Oechsner M, Steen C, Sturenburg HJ, Kohlschutter A. Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency. J Neurol Neurosurg Psychiatry 1998; 64: 680-2.
Coude FX, Grimber G, Parvy P, Rabier D, Petit F. Inhibition of ureagenesis by valproate in rat hepatocytes. Role of N-acetylglutamate and acetyl-CoA. Biochem J 1983; 216: 233-6.
Rumbach L, Cremel G, Marescaux C, et al. Valproate-induced hiperamonemia of renal origin: effects of valproate on glutamine transport in rat kidney mitochondria. Biochem Pharmacol 1989; 38: 3963-7.
Williams CA, Tiefenbach St, McReynolds JW. Valproic acid-indiced hiperamonemia in mentally retarded adults. Neurology 1984; 34: 550-3.
Ohtani Y, Endo F, Matsuda I. Carnitine deficiency and hyperammonemia associated with valproic acid therapy. J Pediatr 1982; 101(5): 782-5.
Gidal BE, Inglese CM, Meyer JF, et al. Diet- and valproateinduced transient hyperammonemia: effect of L-carnitine. Pediatr Neurol 1997; 16: 301.