Torres-Bugarín O, Zavala-Cerna MG, Macriz-Romero N, Flores-García A, Ramos-Ibarra ML

Language: Spanish
References: 22
Page: 4-11
PDF size: 105.49 Kb.

ABSTRACT

The study of occupational risk from exposure to hazardous waste should be a priority since several occupational environments require some contact with mutagenic products and in some instances the necessary security measures are not followed. Furthermore, methods used to evaluate occupational risk are often expensive, complicated and invasive. In contrast, the micronucleus assay (MN) and nuclear abnormalities (NA) in oral mucosa allow microscopic observation of the morphology of surface epithelial cells after collection, fixation and staining. This technique provides an opportunity to monitor the genetic damage in populations with high occupational risks due to genotoxic exposure products, other than that the test is quick, simple, affordable, minimally invasive, relatively painless and well tolerated by patients, furthermore there´s no need for a cellular culture, for these reasons it could be used in the early diagnosis of genotoxic damage resulting from occupational exposure or as a screening test to monitor beneficial effects as a result of changes in life style or specific treatments in diverse pathologies.

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