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2009, Number 3

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Med Sur 2009; 16 (3)

Lesión pulmonar aguda postransfusión: Revisión de un caso y literatura

Carrillo ER, Herrera GJC, Morales ED

Language: Spanish
References: 13
Page: 137-142
PDF size: 234.36 Kb.


ABSTRACT

The term Transfusion Related Acute Lung Injury (TRALI) –condition described in 1983 by Popovsky– is the main cause of death related to blood transfusion. It is defined as a clinical syndrome characterized by acute hypoxemia with non-cardiogenic pulmonary edema after the transfusion of any blood products. Though its patophysiology remains unknown, there are two main theories: direct cellular damage and cytotoxic activity mainly by neutrophills and macrophages to the pulmonary epithelium provoking acute pulmonary edema. It is an exclusion diagnosis and should be considered as an acute lung injury subtype. Its treatment is based on supplementary oxygen and withdrawal of anti-HLA antibodies by hemofiltration thus diminishing inflammation and allowing epithelial repair. Symptoms typically resolve within the first 24 to 96 hours.


REFERENCES

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