medigraphic.com

2013, Number 3

<< Back Next >>

Rev Med Inst Mex Seguro Soc 2013; 51 (3)

Overweight, obesity, diabetes, and hypertension in endometrial cancer

Sanz-Chávez TLN, Vilar-Compte D, de Nicola-Delfín L, Meneses-García A

Language: Spanish
References: 23
Page: 326-329
PDF size: 66.87 Kb.


ABSTRACT

Background: in postmenopausal women, the excess of fat has been associated with an increased risk of endometrial cancer. The aim of the study was to determine the prevalence of overweight, obesity, diabetes and hypertension in patients with endometrial cancer.
Methods: we collected demographic, clinical, laboratory and histopathological information from the electronic records of patients diagnosed with endometrial cancer in the period from January 2009 to July 2011. Subsequently descriptive analysis of the information was done.
Results: a total of 274 records. The average age of patients was 54 years. The 50.4 % were postmenopausal. At the time of diagnosis, 112 cases (48.6 %) were in clinical stage I. Of all patients, 104 (37.9 %) had diabetes mellitus, 122 (44.5 %) hypertension, 194 (72.6 %) were overweight or obese, and 24 cases were registered with the metabolic syndrome.
Conclusions: in regards to this diagnosis the results show a higher incidence of overweight and obesity compared with other countries. It is necessary to conduct further studies to assess the relationship of excess fat as a risk factor for endometrial cancer.


REFERENCES

  1. Carreras-Collado R, Mancebo G. Obesidad y Cáncer de endometrio. Med Clin. 2007;128(5):176-77.

  2. Olaiz-Fernández G, Rivera-Dommarco J, Shamah- Levy T, Rojas R, Villalpando-Hernández S, Hernández- Avila M et al. Encuesta Nacional de Salud y Nutrición 2006. México: Instituto Nacional de Salud Pública; 2006. Texto libre en http://www.insp.mx/ensanut/ensanut2006. pdf

  3. Roland T. Obesity as a disease. Br Med Bull. 1997; 53:307-21.

  4. Wolin KY, Carson K, Colditz GA. Obesity and cancer. Oncologist. 2010:15(6):556-65. Texto libre en http:// www.ncbi.nlm.nih.gov/pmc/articles/PMC3227989/

  5. Xu WH, Xiang YB, Zheng W, Zhang X, Ruan ZX, Cheng JR, et al. Weight history and risk of endometrial cancer among chinese women. Int J Epidemol. 2006;35(1):159-166. Texto libre en http://ije.oxfordjournals. org/content/35/1/159.full.pdf

  6. Kirschner MA, Schneider G, Ertel NH, Worton E. Obesity, androgens, estrogens, and cancer risk. Cancer Res. 1982;42(Supl 8):3281s-3285s.

  7. Folsom AR, Kaye SA, Potter JD, Prineas RJ. Association of Incident Carcinoma of the endometrium with body weight and fat distribution in older women: early fi ndings of the lowa Women´s Health Study. Cancer Res. 1989;49:6828-31. Texto libre en http:// cancerres.aacrjournals.org/content/49/23/6828.long

  8. GLOBOCAN (International Agency for Research on Cancer, IARC) [Internet]. Cervical Cancer Incidence and Mortality Worldwide in 2008. France, 2008. [Consultado el 23 de febrero de 2013]. Disponible en http:// globocan.iarc.fr/factsheets/cancers/cervix.asp

  9. Dossus L, Rinaldi S, Becker S, Likanoa A, Tionneland A, Olsen A et al. Obesity, infl ammatory markers, and endometrial cancer risk: a prospective case-control study. Endocr Relat Cancer. 2010;17(4):1007-19. Texto libre en http://www.ncbi.nlm.nih.gov/pmc/articles/ PMC2966326/

  10. Austin H, Austin JM Jr, Partridge EE, Hatch KD, Shingleton HM. Endometrial cancer, obesity, and body fat distribution. Cancer Res. 1991;51(2):568-72. Texto libre en http://cancerres.aacrjournals.org/content/ 51/2/568.long

  11. Shu XO, Brinton LA, Zheng W, Swanson CA, Hatch MC, Gao YT, et al. Relation of obesity and body fat distribution to endometrial cancer in Shanghai, China. Cancer Res. 1992;52(14):3865-70.

  12. Eyre H, Kahn R, Robertson RM; American Cancer Society, the American Diabetes Association, and the American Heart Association. Collaborative Writing Committee. Preventing cancer, cardiovascular disease, and diabetes: a common agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association. Diabetes Care. 2004;27(7):1812-24.

  13. World Health Organization. Obesity: Preventing and Managing Global Epidemia. Switzerland: WHO; 1998.

  14. International Agency for Research Cancer. Section of Cancer Information. En: GLOBOCAN 2008. Francia: WHO; 2008.

  15. Rouzier R, Legoff S. Cáncer de endometrio. En: EMC Tratado de medicina: Elsevier Masson; 2008.

  16. Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev. 2002;11(12):1531-43.

  17. De Vita VT Jr, Lawrence TS, Rosenberg SA. Cancer: Principles and Practice of Oncology. 9a ed. EUA: Wolters Klower; 2011. p. 1345.

  18. Angulo M, Martínez-Amores Martínez B, Navarro- Expósito F, Álvarez-Mon Soto M. Cáncer de endometrio. Medicine. 2009;10(24):1599-605.

  19. Van Kruijsdijk RC, van der Wall E, Visseren FL. Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomarkers Prev. 2009;18 (10):2569-78.

  20. Sorosky J. Endometrial Cancer. Obstet Gynecol. 2008;111(2 Pt 1):436-47.

  21. Rosato V, Zucchetto A, Bosetti C, Dal Maso M, Montella M, Pelucchi C, et al. Metabolic syndrome and endometrial cancer risk. Ann Oncol. 2011;22(4):884-89. Texto libre en http://annonc.oxfordjournals.org/content/ 22/4/884.long

  22. González MJ, Lejarcegui FL. Adenocarcinoma del endometrio. En: González MJ. Oncología Ginecológica. España: Salvat; 1995. p. 211-254.

  23. Enríquez-Dominguez B, Fuentes-González L, Jova- Rodriguez M, Robaina-Aguirre F. Estudio clinico-epidemiológico del adenocarcinoma del endometrio y sus precursores. Rev Cubana Obstet Ginecol [Internet]. 2003;29(3). Disponible en http://bvs.sld.cu/revistas/gin/ vol29_3_03/gin09303.htm




2020     |     www.medigraphic.com