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2013, Number 3

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Rev Med Inst Mex Seguro Soc 2013; 51 (3)

Implications in primary health care of medical genetics and genomic in type 2 diabetes mellitus

Sergio Alberto Ramirez-Garcia, Carlos E Cabrera-Pivaral, Luis Huacuja-Ruiz, Luis Javier Flores-Alvarado, Guillermo Pérez-García, José Luis González-Rico, Alma López-Velázquez, Luz Rosalba Topete-González, Roberto Carlos Rosales-Gómez, Gerardo Candelario-Mejía, Nemesio Villa-Ruano

Language: Spanish
References: 110
Page: 6-26
PDF size: 677.38 Kb.


ABSTRACT

Type 2 diabetes mellitus is a complex disease and a global health problem. Therefore, the fi rst level of health care should handle the approaches of medical genetics and genomics to reduce its incidence. The aim is to present perspectives analyzed by our group in two areas of genetics and its clinical application. Emphasis is placed on the coexistence of several genetic forms clinically detectable in patients with diabetes, missing heritability associated with low penetrance, and epigenomics mechanism. It is discussed the effect of genetic variation associated with resistance to insulin, beta-cell dysfunction, shaft incretin, and other points of interest, such as thrifty genotype hypothesis, conformational disease, genetically unknown foods, phenocopies as clinically silent hypercortisolism, molecular phytopharmacology in the clinical management. Finally, the result was displayed in the Mexican population from genetic studies and new fi ndings of clinical importance, such as involvement of melatonin and effect of variations in the number of copies in a genomic region.


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