2013, Number 3
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Rev Med MD 2013; 4.5 (3)
Ischemic cardiopathy associated to antiphospholipid syndrome
Hernández-del Rio JE, Becerra-Martínez JC, Galindo-Gil S, Chávez-Alvado JC, Petersen-Aranguren F
Language: Spanish
References: 13
Page: 192-166
PDF size: 581.28 Kb.
ABSTRACT
The antiphospholipid syndrome (APS) is infrequent, characterized by complications associated to a
hypercoagulability. The APS includes clinical characteristics such as arterial or venous thrombosis, coronary arteries
disease, intracardiac thrombus formation, pulmonary hypertension, dilated myocardiopathy and cardiac valve
disease, being the mitral valve the most affected followed by aortic and tricuspid. The diagnostic of APS is done through
the detection of the antiphospholipid antibodies (APLA). Therefore we present a case of a male patient with ischemic
cardiopathy secondary to a primary antiphospholipid syndrome.
REFERENCES
1. Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification riteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295–306
Hughes GR. Hughes syndrome (the antiphospholipid syndrome): ten clinical lessons. Autoimmun Rev. 2008; 7:262–266
Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1000 patients. Arthritis Rheum 2002; 46:1019–1027
Cervera R, Khamashta MA, Shoenfeld Y, et al.Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicentre prospective study of 1000 patients. Ann Rheum Dis 2009; 68:1428–1432
Alonso-Santor JE, Inglada-Galiana L, Pérez-Paredes G. The antiphospholipid syndrome: an update. An Med Interna 2007; 24(5):242-248
Font J, Cervera R. Cardiac manifestations in antiphospholipid syndrome. In: Khamashta MA (ed) Hughes syndrome, 2nd edn, 2006. Springer, London, pp 41–53
Bick RL, Baker WF. Treatment Options for Patients Who Have Antiphospholipid Syndromes. Hematol Oncol Clin North Am. 2008;22(1):145-153.
Soltesz P, Veres K, Lakos G, et al. Evaluation of clinical and laboratory features of antiphospholipid syndrome: a retrospective study of 637 patients. Lupus 2003; 12(4):302–7.
Vaarala O, Alfthan G, Jauhiainen M, et al. Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus. Lancet 1993;341(8850):923–5.
10.Hamsten A, Norberg R, Bjorkholm M, et al. Antibodies to cardiolipin in young survivors of myocardial infarction: an association with recurrent cardiovascular events. Lancet 1986;1(8473):113–6.
11.Morton KE, Gavaghan TP, Krilis SA, et al. Coronar y ar ter y bypass graft failure—an autoimmune phenomenon? Lancet 1986;2(8520):1353–7.
12.Koniari I, Siminelakis SN, Baikoussis NG, Papadopoulos G, Goudevenos J, Apostolakis E. Antiphospholipid syndrome; its implication in cardiovascular diseases: a review. J Cardiothorac Surg. 2010 Nov 3;5:101.
Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GR. The management of thrombosis in the antiphospholipid-antibody syndrome. N Engl J Med. 1995 Apr 13;332(15):993-7