2001, Number 4
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Med Crit 2001; 15 (4)
HELLP-Eclampsia syndrome
Martínez FJI, Aguirre ÁG, Coronado MH
Language: Spanish
References: 17
Page: 121-125
PDF size: 122.14 Kb.
ABSTRACT
Objective: To determine the association of HELLP (hemo-lysis, elevated liver enzymes, and low platelets) syndrome with hypertension in pregnancy (preeclampsia-eclampsia).
Design: Retrospective study.
Setting: Intensive Care Unit of a Communitary Hospital Guadalajara, Mexico.
Patients: Thirty five critically ill obstetric patients. The patients were divided in two groups based on the presence of partial or complete HELLP syndrome with or without hypertension in pregnancy.
Interventions: None.
Measurements and main results: The association of HELLP syndrome with eclampsia was present in 11 (37.9%) and HELLP syndrome without hypertension in pregnancy in six. The diagnosis of complete HELLP syndrome was in 11 (65%), and six (35%) had partial HELLP syndrome. The complications were: renal failure in 23%, intracranial hemorrhage in 6%, acute respiratory distress syndrome in 6%, disseminated intravascular coagulation in 6% and intra-abdominal infection in 3%. Direct obstetric maternal death was observed in four patients.
Conclusions: The association of HELLP syndrome with eclampsia is high in our hospital.
REFERENCES
Weinstein L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count; a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 1982: 142-159.
Mattar F, Sibai BM. Eclampsia. Risk factors for maternal morbidity. Am J Obstet Gynecol 2000; 182: 307-312.
Tompkins MJ, Thiagarajah S. HELLP (hemolysis, elevated liver enzymes, and low platelet count) Syndrome: The benefit of corticosteroids. Am J Obstet Gynecol 1999; 181: 304-309.
López LlM. Main clinical types and subtypes of eclampsia. Am J Obstet Gynecol 1992; 166: 4-9.
Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): Much do about nothing? Am J Obstet Gynecol 1990; 162: 311-316.
Davey DA. MacGillivray IM. The classification and definition of the hipertensive disorders of pregnancy. Am J Obstet Gynecol 1988; 158: 892-898.
Audibert F, Friedman SA, Frangieh AY, Sibai BM. Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Am J Obstet Gynecol 1996; 175: 460-464.
Martin JN, Perry KG, Blake PG, May WA, Moore A, Robinette L. Better maternal outcomes are achieved with dexamethasone therapy for postpartum HELLP (hemolysis, elevated liver enzymes, and thrombocytopenia) syndrome. AM J Obstet Gynecol 1997; 177: 1011-1017.
Trejo Ramírez CA. Mortalidad materna, evolución de su estudio en México en los últimos 25 años. Ginec Obstet (MEX) 1997; 65: 317-325.
Sibai BM, Ramadam MK, Usta I, Salama M, Mercer BM, Friedman SA. Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol 1993; 169: 1000-1006.
Martin JN, Blake PG, Perry KG, McCaul JF, Hess LW, Martin RW. The natural history of HELLP syndrome: Patterns of disease progression and regression. Am J Obstet Gynecol 1991; 164: 1500-1513.
Minakami H, Kohmura Y, Izumi A, Watanabe T, Matsubara S. Sato I. Relation between gestational thrombocytopenia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome). Gynecol Obstet Invest 1998; 46: 41-45.
Witlin AG, Friedman SA, Egerman RS, Frangieh AY, Sibai BM. Cerebrovascular disorders complicating pregnancy-beyond eclampsia. Am J Obstet Gynecol 1997; 176: 1139-1148.
Sibai BM, Taslimi MM, El-Nazer A, Amon E, Mabie BC, Ryan GM. Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia-eclampsia. Am J Obstet Gynecol 1986; 155: 501-509.
Martin JN, Files JC, Blake PG, Norman PH, Martin RW, Hess LW et al. Plasma exchange for preeclampsia. I. Postpartum use for persistently severe preeclampsia-eclampsia with HELLP syndrome. Am J Obstet Gynecol 1990; 162: 126-137.
Reyes Frausto S, Lezana Fernández MA, García Peña MC, Bobadilla Fernández JL. Maternal mortality regionalization and trend in México (1937-1995). Archives of Medical Research 1998; 29: 165-172.
Isler CM, Rinehart BK, Terrone DA, Martin RW, Magann EF, Martin JN. Maternal mortality associated with HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Am J Obstet Gynecol 1999; 181: 924-928.