Leal YA, Gómez A, Madrazo-de la Garza A, Ramos I, Muñoz O, Torres J

Language: English
References: 32
Page: 470-477
PDF size: 71.95 Kb.

ABSTRACT

Background. Helicobacter pylori infection is one of the most common chronic infections in the world, and is acquired mainly during childhood. It is not clear to which extent a primary infection protects the child from reinfection. Our aim was to determine the possible protection conferred by a primary infection against H. pylori reinfection in children. Methods. A follow-up study with 120 children distributed in two cohorts; the first included 80 children without previous H. pylori infection (primo-infection cohort); the second included 40 infected children successfully eradicated (reinfection cohort). Cohorts were monitored during 2 years with urea-breath-test (UBT) at 3, 6, 9, 12, 18 and 24 months for the acquisition of H. pylori infection. We compared the rate of reinfection in eradicated children with the rate of infection in children without previous infection. H. pylori infection during the follow-up was analyzed and compared between cohorts using χ² and survival curves. A questionnaire was performed for the evaluation of possible risk factors for infection in both cohorts. Results. No significant differences in rates of primo-infection or reinfection were found; 17 (21.2%) primo-infections and 10 (25%) reinfections were documented. Most of the primo-infections (14/17) occurred in the first year of follow-up. In contrast, reinfection episodes occurred more frequently during the second year (6/10). In both cohorts, most infections were transient. Risk factors were similar for both, primo and reinfection cohorts. Conclusion. A primary infection does not protect from reinfection in the population of children studied.

REFERENCES

1. Perez-Perez GI, Rothenbacher D, Brenner H. Epidemiology of Helicobacter pylori infection. Helicobacter 2004; 9(Suppl. 1): 1-6.

2. Malaty HM. Epidemiology of Helicobacter pylori infection. Best Pract Res Clin Gastroenterol 2007; 2: 205-14.

3. Torres J, Leal-Herrera Y, Perez-Perez G, Gomez A, Camorlinga- Ponce M et al. A community-based seroepidemiologic study of Helicobacter pylori infection in Mexico. J Infect Dis 1998; 178(4): 1089-94.

4. Imrie C, Rowland M, Bourke B, Drumm B. Is Helicobacter pylori infection in childhood a risk factor for gastric cancer? Pediatrics 2001; 107: 373-80.

5. Peek RM Jr., Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2002; 2(1): 28-37.

6. Haggerty TD, Perry S, Sanchez L, Perez-Perez GI, Parsonnet J. Significance of transiently positive Enzyme-Linked Immunosorbent Assay results in detection of Helicobacter pylori in stool samples from children. J Clin Microbiol 2005; 43: 2220-23.

7. Leal-Herrera Y, Torres J, Monath TP, Ramos I, Gomez A, et al. High rates of recurrence and of transient reinfections of Helicobacter pylori in a population with high prevalence of infection. Am J Gastroenterol 2003; 98: 2395-402.

8. Klein PD, Gilman RH, Leon-Barua R, Diaz F, Smith EO, Graham DY. The epidemiology of Helicobacter pylori in Peruvian children between 6 and 30 months of age. Am J Gastroenterol 1994; 89: 2196-200.

9. Perri F, Pastore M, Clemente R, Festa V, Quitadamo M, Niro G, et al. Helicobacter pylori infection may undergo spontaneous eradication in children: a 2-year follow-up study. J Pediatr Gastroenterol Nutr 1998; 27: 181-3.

10. Rothenbacher D, Inceoglu J, Bode G, Brenner H. Acquisition of Helicobacter pylori infection in a high-risk population occurs within the first 2 years of life. J Pediatr 2000; 136: 744-8.

11. Torres J, Perez-Perez G, Goodman KJ, Atherton JC, Gold BD, et al. A comprehensive review of the natural history of Helicobacter pylori infection in children. Arch Med Res 2000; 31: 431-69.

12. O’Rourke K, Goodman KJ, Grazioplene M, Redlinger T, Day RS. Determinants of geographic variation in Helicobacter pylori infection among children on the US-Mexico border. Am J Epidemiol 2003; 158: 816-24.

13. Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, Yamaoka Y, Berenson GS. Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood. Lancet 2002; 359: 931-5.

14. Perez-Perez GI, Sack RB, Reid R, Santosham M, Croll J, Blaser M. Transient and persistent Helicobacter pylori colonization in native American children. J Clin Microbiol 2003; 41: 2401-7.

15. Khanna B, Cutler A, Israel NR, Perry M, Lastovica A, et al. Use caution with serology testing for Helicobacter pylori infection in children. J Infect Dis 1998; 178: 460-5.

16. Gold BD, Goodman K. Helicobacter pylori infection in children: to test or not to test...what is the evidence? J Pediatr 2000; 136: 714-16.

17. Rowland M, Lambert I, Gormally S, Daly LE, Thomas JE, et al. Carbon 13-labeled urea breath test for the diagnosis of Helicobacter pylori infection in children. J Pediatr 1997; 131: 815-20.

18. Kato S, Ozawa K, Konno M, Tajiri H, Yoshimura N, et al. Diagnostic accuracy of the 13C-urea breath test for childhood Helicobacter pylori infection: a multicenter Japanese study. Am J Gastroenterol 2002; 97: 1668-73.

19. Yañez P, Madrazo de la Garza AM, Perez-Perez G, Cabrera L, et al. Comparison of invasive and noninvasive methods for the diagnosis and evaluation of eradication of Helicobacter pylori infection in children. Arch Med Res 2000; 31: 415-21.

20. Gold BD, Colletti RB, Abbott M, Czinn SJ, Elitsur Y, et al. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr 2000; 31: 490-7.

21. Czinn SJ. Helicobacter pylori infection: detection, investigation and management. J Pediatr 2005; 146 (Suppl 3): S21-S26.

22. Yoshimura N, Tajiri H, Sawada A, Kozaiwa K, Ida S, et al. A 13C-urea breath test in children with Helicobacter pylori infection: assessment of eradication therapy and follow-up after treatment. J Gastroenterol 2001; 36(9): 606-11.

23. Nugalieva ZZ, Opekun AR, Graham DY. Problem of distinguishing false-positive test from acute or transient Helicobacter pylori infections. Helicobacter 2006; 11: 69-74.

24. Goodman KJ, O’Rourke K, Day RS, Wang C, Nurgalieva Z, Phillips CV, Aragaki C, Campos A, de la Rosa JM. Dynamics of Helicobacter pylori infection in a US-Mexico cohort during the first two years of life. Int J Epidemiol 2005; 34: 1348-55.

25. Graham DY, Malaty HM, Evans DG, Evans DJ Jr, Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States, effect of age, race, and socioeconomic status. Gastroenterology 1991; 100: 1495-501.

26. Gonzalez-Valencia G, Atherton JC, Muñoz O, Dehesa M, Madrazo de la Garza AM, Torres J. Helicobacter pylori vacA and cagA genotypes in Mexican adults and children. J Infect Dis 2000; 182: 1450-4.

27. Munoz L, Camorlinga M, Hernandez R, Giono S, Ramon G, Munoz O, Torres J. Immune and proliferative cellular responses to Helicobacter pylori infection in the gastric mucosa of Mexican Children. Helicobacter 2007; 12: 224-30.

28. Kutukculer N, Aydogdu S, Goksen D, Caglayan S, Yagcyi RV. Increased mucosal inflammatory cytokines in children with Helicobacter pylori-associated gastritis. Acta Paediatr 1997; 86: 928-31.

29. Nedrud JG, Blanchard SS, Czinn SJ. Helicobacter pylori inflammation and immunity. Helicobacter 2002; 7(Suppl. 1): 24-9.

30. Windle HJ, Kelleher D, Crabtree JE. Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle? Pediatrics 2007; 119: e754-e759.

31. Rowland M, Daly L, Vaughan M, Higgins A, Bourke B, Drumm B. Age-specific incidence of Helicobacter pylori. Gastroenterology 2006; 130: 65-72.

32. Wizla-Derambure N, Michaud L, Ategbo S, Vincent P, Ganga- Zandzou S, et al. Familial and community environmental risk factors for Helicobacter pylori infection in children and adolescents. J Pediatr Gastroenterol Nutr 2001; 33: 58-63.