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ISSN 1561-3070 (Electronic)

2012, Number s1

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Rev Cub Oftal 2012; 25 (s1)

Trabecular physiology and open angle glaucoma

Martín PY, Piloto DI, Álvarez CG, Fumero GF, Rodríguez RD, Sánchez AL

Language: Spanish
References: 23
Page:
PDF size: 66.91 Kb.


ABSTRACT

Glaucoma is one of the most common eye diseases worldwide, but usually the problem lies in the evacuation of aqueous humor at the trabecular meshwork and Schlemm's canal. A literature review was made about the main mechanisms involved in the trabecular function: the phagocytic capacity of trabecular cells, the regulation of the extracellular matrix composition, the contraction-relaxation of trabecular cells and the changes in their volume and shape. A better understanding of the trabecular physiology and the pathophysiology of glaucoma will allow better disease management and development of new drugs that have as their target the trabecular pathway in a selective way and that avoid the side effects associated with the use of nonspecific drugs.


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