Arrronte AMT, Delgado MVM, Rodríguez VJ, Rodríguez RT, González BY, Padilla DB

Language: Spanish
References: 34
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ABSTRACT

Objective: to evaluate the central corneal thickness in healthy individuals, in persons with ocular hypertension, and in suspected glaucoma and glaucomatous people, and its influence in intraocular pressure.
Methods: a cross-sectional and descriptive study was performed in 708 eyes from 356 people who had been seen at ophthalmology service of “Dr. Miguel Enríquez”, university hospital from January to December, 2010. Their central corneal thickness was measured with ultrasonic pachymetry (pachymeter US 4000). The rest of the information came from the clinical histories of the patients.
Results: Most of the ocular hypertensives presented thick corneas (p=0,07); a high number of cases that had diagnosis of glaucoma suspicion and primary open-angle glaucoma showed thin corneas (p=0,62 and (p=0,08 respectively). If the correction factor to evaluate the IOP had not been considered, then 48,1 % of the glaucomatous patients and 31,5 % of the ocular hypertensives would have been inadequately diagnosed (p<0,0001).
Conclusions: the majority of the ocular hypertensive patients had thick corneas; however, the biggest number of cases that had diagnosis of suspected glaucoma and primary open angle glaucoma showed thinner corneas. Keeping in mind the correction factor in the evaluation of the intraocular pressure reduces the diagnostic errors.

REFERENCES

1. Leske MC, Wu S, Nemesure B, Hennis A, Barbados Eye Studies Group. Causes of visual loss and their risk factors: an incidence summary from the Barbados Eye Studies. Rev Panam Salud Pública. 2010;27(4):259-67.

2. Skuta GL, Cantor LB, Weiss JS. Glaucoma. En: Basic and clinical science course. American Academy of Ophthalmology. The Eye M.D. Association, 2008-2009 Edition (5).

3. Brandt JD, Beiser JA, Kass MA, Gordon MO. Central corneal thickness in the ocular hypertension treatment study (OHTS). Ophthalmol. 2001;108(10):1779-88.

4. Gordon MO, Beiser JA, Brandt JD, Heuer DK. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120(6):714-20.

5. Alezzandrini A, Frick M, Della Savia L, López M. Estudio Comparativo de Medición del Espesor Corneal Central Utilizando Paquimetría Ultrasónica y Pentacam. Arch Oftal B Aires. 2009;2(80):71-3.

6. Pandolfi A. Computational Biomechanics of the Human Cornea. En: Suvranu D, Guilak F, Mofrad RKM. Computational Modeling in Biomechanics. Holanda: Springer Netherlands; 2010. p. 435-66.

7. Kohlhaas M, Boehm AG, Spoerl E, Pürsten A, et al. Effect of Central Corneal Thickness, Corneal Curvature, and Axial Length on Applanation Tonometry. Arch Ophthalmol. 2006;124(4):471-6.

8. Wheeler NC, Morantes CM, Kristensen RM, Pettit TH, Lee DA. Reability coeficients of three corneal pachymeters. Am J Ophthalmol. 1992;113(6):645-51.

9. Drexelr W, Baumgartner A, Findl O, Hitzenberger CK, Sattmann H, Fercher AF. Submicrometer precision biometry of the anterior segment of the human eye. Invest Ophthalmol Vis Sci. 1997;38(7):1304-13.

10. Hitzenberger CK, Baumgartner A, Drexler W, Fercher AF. Interferometric measurement of corneal thickness with micrometer precision. Am J Ophthalmol. 1994;118(4):468-76.

11. Bovelle R, Káufman SC, Thompson HW, Hamano H. Corneal thickness measurements with the Topcon SP 2000 P specular microscope and an ultrasound pachymeter. Arch Ophthalmol. 1999;117(7):868-70.

12. Keisuke K, Kazunori M, Tadatoshi T, Takahiro K, Hiraoka, Tetsuro O. Central corneal thickness measurements using Orbscan II Scanning Slit Topography, Noncontact Specular Microscopy, and Ultrasonic Pachymetry in eyes with keratoconus. Clinical Sciences. 2005;8(24):967-71.

13. Dubois A, Grieve K, Moneron G, Lecaque R, Vabre L, Boccara C. Ultrahigh-Resolution Full-Field optical coherence tomography. Applied Optics. 2004;14(43):2874-83.

14. Kawana K, Tokunaga T, Miyata K, Okamoto F, Kiuchi T, Oshika T. Comparison of corneal thickness measurements using Orbscan II, non-contact specular microscopy, and ultrasonic pachymetry in eyes after laser in situ keratomileusis.. Br J Ophthalmol. 2004;88(4):466-8.

15. Sanchís-GJ, Lleó PA, Alonso L, Rahhal M. Paquimetría Orbscan: Diferencias entre observadores al realizar mediciones del espesor corneal. Arch Soc Esp. 2005;80(5):283-8.

16. Boscia F, La Tegola MG, Alessio G, Sborgia C. Acuracy of Orbscan optical pachymetry in corneas with haze. J Cataract Refract Surg. 2002;28(2):253-8.

17. Feltgen N, Leifert D, Funk J. Correlation between central corneal thickness, applanation tonometry, and direct intracameral IOP readings. Br J Ophthalmol. 2001;85(1):85-7.

18. Francis BA, Varma R, Chopra V, Lai MY, Shtir C, Azen SP and Los Angeles Latino Eye Study Group. Intraocular pressure, central corneal thickness, and prevalence of open-angle glaucoma: The Los Angeles Latino Eye Study. Am J Ophthalmol. 2008;146(5):741-6.

19. Doughty MJ, Zaman ML. Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol. 2000;44(5):367-408.

20. Varma R, Paz SH, Azen SP, Klein R, Globe D, Torres M, et al. The Angeles Latino Eye Study. Design, methods and baseline data. Ophthalmology. 2004;111(6):1121-31.

21. The World Medical Association. Declaration of Helsinki. 52nd WMA General Assembly. Edimburgh, Scotland: The Association; 2000.

22. Díaz Alemán VT, Fernandez-Banca Vaca G, Lozano Lopez V, Garcia Somalo M, Perera Sanz D, Gonzalez de la Rosa M. Nomograma de riesgo de progreso de hipertensión ocular basado en el Ocular Hypertension Treatment Study. Arch Soc Esp Oftalmol. 2005;80(3):151-4.

23. Rueda JC, Lesmes DP, Parra JC, Urrea R, Rey JJ, Rodriguez LA, et al. Valores de paquimetría en personas sanas y con glaucoma en la población colombiana. MedUNAB 2007;10(2):81-5.

24. Triana Casado I, Medina Perdomo JC. Espesor Corneal Central y Otros Factores de Riesgo del Glaucoma Primario de Ángulo Abierto. Rev Misión Milagro. 2009 [citado 23 de febrero de 2012];3(1). Disponible en: http://www.misionmilagro.sld.cu/vol3no1/inv3105.php

25. Luna-Martínez C. Relación del espesor corneal central y la variación en la presión intraocular con daño al nervio óptico en pacientes mexicanos con glaucoma. Rev Mex Oftalmol. 2009;83(4):193-6.

26. Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120(6):701-13.

27. The AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 2000;130(4):429-40.

28. Ríos González LC. Detección de glaucoma: corrección de PIO por modificaciones del grosor corneal. Rev Mex Oftalmol. 2009;83(5):284-7.

29. Shih CY, Graff Zivin JS, Trokel SL, Tsai JC. Significado clínico del espesor corneal central en el tratamiento del glaucoma. Glaucoma J. 2005;14(5):337-43.

30. Medeiros FA, Weinreb RN. Evaluación del riesgo de glaucoma e hipertensión ocular. Construcción de un modelo de riesgo para desarrollo y progresión de glaucoma. International Ophthalmology Clinics. 2009;48(4):1-12.

31. Gunvant P, O'Leary DJ, Baskaran M. Evaluation of tonometric correction factors. Glaucoma J. 2005;14(5):337-43.

32. Martinez-de-la-Casa JM, Garcia-Feijoo J, Vico E, Fernandez-Vidal A, Benitez del Castillo JM, Wasfi M. Effect of corneal thickness on dynamic contour, rebound, and goldmann tonometry. Ophthalmology. 2006;113(12):2156-62.

33. Heras M, Moreno MJ, Sadaba ELM, Mendiluce ML. Comparison of dynamic contour tonometry with pneumotonometry and Goldmann tonometry. Arch Soc Esp Oftalmol. 2007;82(6):337-41.

34. Pache M, Wilmsmeyer S, Lautebach S, Funk J. Dynamic contour tonometry versus Goldmann applanation tonometry: a comparative study. Graefes Arch Clin Exp Ophthalmol. 2005;243(8):763-7.