Parlá SJ

Language: Spanish
References: 12
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ABSTRACT

Hypothyroidism is the clinical picture resulting from the reduction of thyroid hormone production. It affects 1 to 2 % of the general population. It is classified from the anatomical and etiological viewpoint and the presence or absence of goiter. The diagnosis is clinical (questioning and physical exam) and humoral (high TSH levels and low free T3 and T4 levels). The treatment is aimed at eliminating the deficiency of thyroid hormones until clinical and biochemical euthyroidism is achieved. The replacement treatment with thyroid hormone is lifelong at a dose of 1.7 µg/kg/day. The level of TSH indicates the individual optimal dose of sodium levothyroxine that should be used.

REFERENCES

1. Mayayo Dehesa E. Hipotiroidismo y Bocio. Protoc Diagn Ter Pediatr. 2011;1:150-65.

2. Carle A, Pedersen IB, Knudsen N, Perrild H, Ovesen L, Jorgensen T, et al. Thyroid volume in hypothyroidism due to autoimmune disease follows a unimodal distribution: evidence against primary thyroidatrophy and autoimmune thyroiditis being distinct diseases. J Clin Endocrinol Metab. 2009;94:833-9.

3. Sharma R, Sharma TK, Kaushik GG, Sharma S, Vardey SK, Sinha M. Subclinical hypothyroidism and its association with cardiovascular risk factors. Clin Lab. 2011;57(9-10):719-24.

4. Sala FM, Martín L, SanMarti S. Enfermedades del Tiroides. Farreras & Rozman. Medicina Interna. Décimocuarta edición. Madrid: Harcourt; 2000. p. 255,2323-66.

5. Colectivo de autores. Taller Nacional sobre Enfermedades del Tiroides. Rev Cubana Endocrinol. 2004;15(1):11-72.

6. Anderson G, Mariash C, Oppenheimer J. Molecular actions of thyroid hormone. In: Braverman L, Utiger R, eds. Werner & Ingbar's. The Thyroid: a fundamental and clinical text. 8th ed. Philadelphia: Lippincott, Williams, & Wilkins; 2000. p. 174-95.

7. Colectivo de autores. Guía de consenso para el diagnóstico y seguimiento de la enfermedad tiroidea. Acta Bioquím Clín Latinoam. 2007;41(1):87-119.

8. Greenspan FS. Thyroid disease. Med Clin North Am. 2003;75;1.

9. Vaidya B, Pearce SH. Manejo del hipotiroidismo en adultos. BMJ. 2008;337:a801.

10. Rodríguez Arnao MD, Rodríguez Sánchez A, Pose Cabarcos AF, Rodríguez Arnao J. Tratamiento del hipotiroidismo. An Esp Pediatr. 2002;56(Supl 4):53-61.

11. Mechanick JI, Bergman DA, Braithwaite SS, Palumbo PJ, American Association of Clinical Endocrinologists Ad Hoc Task Force for Standardized Production of Clinical Practice Guidelines. American Association of Clinical Endocrinologists protocol for standardized production of clinical practice guidelines (erratum in: Endocr Pract. 2008;14:802-803). Endocr Pract. 2004;10:353-61.

12. Celi FS, Zemskova M, Linderman JD, Babar NI, Skarulis MC, Csako G, et al. The pharmacodynamic equivalence of levothyroxine and liothyronine. A randomized, double blind, cross-over study in thyroidectomized patients. Clin Endocrinol (Oxf). 2010 May;72(5):709-15.