Quintanar EMA, Calderón SJV

Language: Spanish
References: 11
Page: 85-89
PDF size: 63.82 Kb.

ABSTRACT

The eryptosis is a type of apoptosis that takes place in the erythrocyte. This phenomenon has recently been characterized and studied under this approach. The eriptosis shares mechanisms that are typical of apoptosis final stages, including proteases activation, externalization of phosphatidylserine and apoptotic microvesicles formation. The eryptosis is important to avoid the hemolysis, as well as the inflammatory or immunological responses in erythrocytes destruction. In a very interesting way, it is possible to suggest that the eryptosis is the end of an apoptosis that initiated when the erythroblast was maturating to become an erythrocyte. In order to be converted into an erythrocyte, the erythroblast has to lose the mitochondrias and the nucleus, which happens through a partial apoptosis. The erythroblast apoptosis is stopped by a differentiation stimulus and by erythopoietin antiapoptotic activity. In the present work the molecular aspects that induce the partial apoptosis and the final eryptosis of the erythrocytes are described.

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