Rendón DA, López DF

Language: Spanish
References: 27
Page: 130-135
PDF size: 138.79 Kb.

ABSTRACT

The enzymatic activity of the mitochondrial oligomycin-sensitive ATPase was investigated during isoproterenol-induced cell injury of myocardium, using rat heart homogenates and a potentiometric method. The enzymatic activity of the oligomycin-sensitive ATPase and the inhibitory action of oligomycin do not show significant alterations upon treatment with isoproterenol. These results are inconsistent with the hypothesis that modifications in the active configuration of the mitochondrial ATPase take place during isoproterenol-induced injury of myocardium.

REFERENCES

1. Rona G, Chappel CI, Balazs T, Gaudry R: An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. Arch Pathol 1959; 67: 443-455.

2. Rona G, Boutet M, Huttner Y: Reperfusion injury. A possible link between catecholamine-induced and ischemic myocardial alterations. Adv Cardiol 1983; 4: 427-39.

3. Cebelin MS, Hirsch CS: Human stress cardiomyopathy. Hum Pathol 1980; 11: 123-132:

4. Mello de Oliveira JA: Enzyme histochemistry of the heart in chronic phase of the experimental trypanosomiasis CT (T. cruzi) in rats. Rev Goiana Med 1976; 22: 1-65.

5. Chagoya de Sánchez V, Hernández-Muñoz R, López-Barrera F, Yañez L, Vidrio S, Suárez J, et al: Sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats: a long-term and integrative study. Can J Physiol Pharmacol 1997; 75: 1300-1311.

6. Curti C, Uyemura SA, Grechi MJ, Leone FA: Kinetic properties of mitochondrial ATPase during isoproterenol-induced cardiomyopathy. Int J Biochem 1990; 22 (6): 611-615.

7. Hatefi Y: The mitochondrial electron transport and oxidative phosphorylation system. Annu Rev Biochem 1985; 54: 1015-1069.

8. Gomez-Puyou MT, Martins OB, Gomez-Puyou A: Synthesis and hydrolysis of ATP by the mitochondrial ATP synthase. Biochem Cell Biol 1988; 66: 677-682.

9. Capozza G, Muolo L, Jirillo E, Guerrieri F: Isoproterenol causes changes in the mitochondrial energy metabolism in the rat heart. Cardiologia 1992; 37(9): 663-665.

10. Wexler BC: Isoprenaline-induced myocardial infarction in spontaneously hypertensive rats. Cardiovasc Res 1979; 13: 450-457.

11. Bhimji S, Godin DV, McNeill JH: Isoproterenol-induced myocardial ischemic injury in the rabbit: functional and ultrastructural alterations. Acta Anat 1986; 127: 205-211.

12. Veksler V, Kuznetsov AV, Sharov VG, Kapelko VI, Saks VA: Mitochondrial respiratory parameters in cardiac tissue: a novel method of assessment by using saponin-skinned fibers. Biochem Biophys Acta 1987; 892(2): 191-196.

13. Voldyrev AA: Potenstiometricheskii metod opridilenia aktivnosti ATFaz. In Mosk Un-ta. “Transportniie adenozintrifosfatazi”. Moscow, Izd-vo Mosk Un-ta, 1977: 69-78.

14. Gornall AG, Bardawill CJ, David MM: Determination of serum proteins by means of the biuret reaction. J Biol Chem 1949; 177: 751-766.

15. Zhao D, Dhalla NS: Characterization of rat heart plasma membrane Ca2+/Mg2+ ATPase. Arch Biochem Biophys 1988; 263(2): 281-292.

16. Dhalla NS, Zhao D: Possible role of sarcolemmal Ca2+/Mg2+ ATPase in heart function. Magnesium Res 1989; 2(3): 161-172.

17. Charnock JS, Post RL: Evidence of the mechanism of ouabain inhibition of cation activated adenosine triphosphatase. Nature 1963; 199: 910-911.

18. Whittam R, Wheeler KP, Blake A: Oligomycin and active transport reactions in cell membranes. Nature 1964; 203: 720-724.

19. Glynn IM: “Transport adenosinetriphosphatase” in electric organ. The relation between ion transport and oxidative phosphorylation. J Physiol 1963; 169: 452-465.

20. Van Groningen HEM, Slater EC. The effect of oligomycin on the (Na++ K+)-activated magnesium-ATPase of brain microsomes and erythrocyte membrane. Biochem Biophys Acta 1963; 73: 527-530.

21. Järnefelt J: Properties and possible mechanism of the Na+ and K+- stimulated microsomal adenosinetriphosphatase. Biochem Biophys Acta 1962; 59: 643-654.

22. Fahn S, Koval GJ, Albers RW: Sodium-Potassium-activated adenosine triphosphatase of electrophorus electric organ. I. An associated sodium-activated transphosphorylation. J Biol Chem 1966; 241(8): 1882-1889.

23. Fahn S, Hurley MR, Koval GJ, Albers RW: Sodium-Potassium-activated adenosine triphosphatase of electric organ. II. Effects of N-ethylmaleimide and other sulfhydryl reagents. J Biol Chem 1966; 241(8): 1890-1895.

24. Plesner L, Plesner IW: Kinetics of oligomycin inhibition and activation of Na+/K+-ATPase. Biochem Biophys Acta 1991; 1076: 421-426.

25. Skou JC: The influence of some cations on an adenosine triphosphatase from peripheral nerve. Biochem Biophys Acta 1957; 23: 394-401.

26. Bogucka K, Wojtczak L: Intramitochondrial distribution of magnesium. Biochem Biophys Res Commun 1971; 44(6): 1330-1337.

27. Senior AE: Tightly bound magnesium in mitochondrial adenosine triphosphatase from beef heart. J Biol Chem 1979; 254(22): 11319-11322.