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2013, Number 1

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Revista Cubana de Angiología y Cirugía Vascular 2013; 14 (1)

Evaluation of the anti-edematogenic action of Calendula officinalis L. extract of domestic production

Alfonso VMA, Quintela PAM, García MM

Language: Spanish
References: 16
Page:
PDF size: 114.62 Kb.


ABSTRACT

Introduction: Calendula officinalis is a well-known plant used by its therapeutic qualities. Blood vessel protection is attributed to the extracts from its flowers. Objective: to evaluate the anti- edematogenic action of the extract from national Calendula officinalis leaves.
Methods: one hundred twenty Wistar rats divided into four groups of 30 animals were used; one group control and three with C. Officinalis extract concentrations of 50, 100 and 200 mg/kg of weight, respectively, which were orally administered for 3,7 and 14 days. Histamine and the Dextrane A were the edematogenic agents. The edemas appeared in the rats' back were measured to estimate the area.
Results: there was a decrease (p < 0.05) in the edema area induced by histamine and the dextrane A in three groups treated with C. officinalis extract. For both a edematogenic agents, the results were similar and not significant for 50 and 100 mg/kg of weight, although the decrease was substantial (p < 0.05) with the dose of 200 mg/kg. The reduction of the edema depended on the length of treatment.
Conclusions: The anti-edematogenic action of the C. officinalis extract was shown, being the 200 mg/kg dose the best and the 14-day length of treatment the most effective. It was recommended to use it as phlebotonic agent in the treatment of the venous vascular disorders.


REFERENCES

  1. Lastra Valdés H, Piquet García R. Caléndula officinalis. Rev Cubana Farm. 1999 [citado15 Sept 2012];33(3):188-94. Disponible en: http://scielo.sld.cu/pdf/far/v33n3/far07399.pdf

  2. Avramova S, Portarska R, Apostolova S. S ource of new products for the cosmetic industry. Med Biol Inform. 1988;4:24-6.

  3. Acosta de la Luz L, Rodríguez Ferradá C, Sánchez Govín E. Instructivo técnico de Caléndula officinalis. Rev Cubana Plant Med . 2001 [citado15 Sept 2012];6(1):23-7. Disponible en: http://scielo.sld.cu/pdf/pla/v6n1/pla06101.pdf

  4. Muñoz Centeno LM. Plantas medicinales españolas: Caléndula officinalis L. (Asteraceae). Medicina Naturista. 2004;5:257-61.

  5. Fleischner AM. Plants extract to accelerate healing and reduce inflammation. Cosmet Toilet. 1985;100:45-58.

  6. García Bacallao L, Rojo Domínguez DM, Gómez Gómez LV, Hernández Ángel M. Plantas con propiedades antinflamatorias. Rev Cub Invest Biomed. 2002 [citado15 Sept 2012];21(3):214-6. Disponible en: http://scielo.sld.cu/pdf/ibi/v21n3/ibi12302.pdf

  7. Romisarenko N. Flavonoids of influorescences of C. officinalis. Khim Prir Soedin. 1988;6:795-801.

  8. Raju S, Neglén P. Chronic venous insufficiency and varicose vein. NEJM. 2009;360(22):2317-9.

  9. Charles-Edouard Otrante D, Quiñones Castro M, Borrás Migues M, Rodríguez Villalonga LE, Chirino Díaz L. Insuficiencia venosa crónica y calidad de vida. Rev Cubana Angiol Cir Vasc. 2010 [citado15 Sept 2012];11(1):27-33. Disponible en: http://bvs.sld.cu/revistas/ang/vol11_01_10/ang04110.pdf

  10. Coleridge-Smith. The drug treatment of chronic venous insufficiency and venous ulceration. Forum. 2 ed. London: Arnould; 2001.

  11. Lagrue G, Behar A. Evaluation par scanning á albumine marquèe au technétium 99 des propriétés amique de Daflón 500 mg sur la perméabilité capillaire. Concilia Medica. 1989;39(11-8):882-5.

  12. Duran V, Matec M, Jaranove M, Mimica N. Results of clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int J Tissue React. 2005;27:101-6.

  13. Omelchuk MA, Krivut BA, Voroshilov A. Efectos de las condiciones de secado en la calidad de la Calendula officinalis como materia prima para medicamentos. Khim Farm Zh. 1984;18(3):329-31.

  14. Sharapin N. Fundamentos de tecnología de productos fitoterapéuticos. Santa Fe de Bogotá D.C.: Roberto Pinzón; 2000.

  15. Norma Ramal. NRSP 323. Medicamentos de origen vegetal. Flores de Caléndula. Especificaciones. La Habana: MINSAP; 1992.

  16. Alfonso Valiente MA, García Mesa M, García Lazo G, Sánchez Hernández D, Duperon del Sol D, Lemus Dávila R. Acción antiedemagénica de los extractos de corteza del fruto de Citrus sinensis L. y Citrus aurantiun L. en modelo de hiperpermeabilidad vascular en ratas. Rev Cubana Plant Med. 2008 [citado15 Sept 2012];13(4). Disponible en: http://bvs.sld.cu/revistas/pla/vol13_4_08 /pla04408.htm




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