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ISSN 1025-0255 (Electronic)

2012, Number 6

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AMC 2012; 16 (6)

Intensive pharmacovigilance of adrenergic agonists used in the severe patient care

Avila PYR, Lluch BA, Rodríguez PA, Águila HM, Méndez MMC

Language: Spanish
References: 23
Page: 1675-1692
PDF size: 326.69 Kb.


ABSTRACT

Backghround: pharmacovigilance is a branch of Pharmacology of recent development. It arises by events triggered with the pharmacological explosion after the Second World War, which allowed great advances in the treatment of diseases which before lead to a rapid and inexorably death or a severe disability. Objective: to observe treatments administered with adrenergic agonists used in the severe patient. Methods: a prospective observational study was performed on patients who were treated with adrenergic agonists in the intermediate care unit at the Municipal Hospital Manuel "Piti" Fajardo, Florida, Camagüey; from January to July 2010. The sample was constituted by 71 patients. The study took into account sociodemographic and epidemiological variables, type and degree of severity, causation, mechanisms of production of drug adverse reactions, as well as their final outcome. Results: more than fifty percent of patients with suspicion of adverse drug reaction was obtained to predominance of those in which were detected manifestations such as tachycardia, pallor and hypertension between signs and symptoms, according to adrenergic agonist was observed (type A) effects in those who acquired a moderate degree of severity, classified as proven, where the greatest percent of the sample needed treatment to the resolution of symptoms. Conclusions: a significant percent of patients highlighted who received treatment with adrenergic agonists in which suspected drug adverse reactions was detected to predominance in women over 50 years old, tachycardia as the most frequent manifestation in those classified as (type A) effects, regarded as moderate severity of tested type, which needed treatment to achieve the resolution of symptoms, the greatest percent of the sample studied were recovered without after-effects.


REFERENCES

  1. Valselcia-Malgor ME. Farmacología General. 1 ed. [Internet]. Argentina: Universidad Nacional del Nordeste; 2008 [citado 2 Sep 2011]. Disponible en http://med.unne.edu.ar/catedras/farmacologia/tefarm.htm

  2. Routledge PA, O'Mahony MS, Woodhouse KW. Adverse drug reactions in elderly patients. Brit J Clin Pharmacol. 2005;57:121-6.

  3. International Monitoring of Adverse Reactions to drugs. Adverse reaction terminology. The Uppsala Monitoring Centre. Uppsala, Sweden: WHO; 2007.

  4. Laporte JR, Tognoni G. Estudios de utilización de medicamentos y de farmacovigilancia. En: Laporte JR. Tognoni G, editores. Principios de epidemiología del medicamento. 2da. ed. Barcelona: Masson-Salvat; 2006.p.1-19.

  5. Rego Hernández JJ, Leyva de la Torre C, Pérez Sánchez M. Pesquisaje activo de sospechas de reacciones adversas a medicamentos en el Hospital "Dr. Salvador Allende". Primer semestre 2006. Rev Cubana Farm [Internet]. 2007 Set-Dic [citado 12 Oct 2010]; 41(3):[aprox. 10 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152007000300007&lng=es&nrm=iso&tlng=es

  6. Rodríguez Duque R, Jiménez López G, Fernández Manchón E, González Delgado B. Caracterización de las reacciones adversas medicamentosas en ancianos. Cuba, 2003-2005. Rev Cubana Farm [Internet]. 2007 Set-Dic [citado 12 Oct 2010];41(3):[aprox. 15 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152007000300002&lng=es&nrm=iso&tlng=es

  7. Quesada Arguedas J. Detección y reporte de las reacciones adversas a los medicamentos. AMD [Internet]. 2006 Feb [citado 12 Oct 2010] 23(57). Disponible en: http://www.ampmd.com.

  8. Alonso Carbonell A, García Milián AJ, López Puig P, Yera Alós I, Blanco Hernández N. Patrón de reacciones adversas a medicamentos referidas por la población mayor de 15 años. Rev Cubana Med Gen Integr. 2009;25(1):67-76.

  9. Plaza J. interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos. Rev Med Chile. 2010;138:452-60.

  10. OMS. Punto de vista. Parte 1. Uppsala. The Uppsala Monitoring Centre; 2006

  11. Naranjo CA. Algoritmo Karch y Lasagna modificado por Naranjo. Clin Pharmacol Ther. 1981;30:239-45.

  12. Blenkinsopp A, Wilkie P, Wang M, Routledge PA. Patient reporting of suspected adverse drug reactions: a review of published literature and international experience. Br J Clin Pharmacol. 2007;63(2):148-56.

  13. Collazo Herrera M, Flores Díaz N. Farmacoeconomía. Evaluación de la eficiencia en los tratamientos farmacológicos. Rev Cubana de Farm [Internet]. 2000 Ene-Abr [citado 12 Oct 2010];34(1):[aprox. 6 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152000000100009&lng=es&nrm=iso&tlng=es

  14. Carrara C, Cuper P, Gonseski P, Rolli V, Morales S, Valsecia M. Reacciones Adversas a Medicamentos en los Servicios de Emergencia Hospitalarios de la Ciudad de Corrientes. Universidad Nacional del Nordeste. Corrientes. Comunicaciones Científicas y Tecnológicas [internet]. 2004. Disponible en: http://www.unne.edu.ar

  15. OMS. Seguridad de los medicamentos. Reacciones adversa a medicamentos. Nota descriptiva No. 293. Septiembre 2005. [Internet]. Disponible en: http://www.who.int/mediacentre/.

  16. Castillo Y, Valenzuela E. Fármacos en el adulto mayor [Internet]. Chile: Póntifice Universidad de Chile; 2012 [citado 12 Oct 2012]. Disponible en: http://escuela.med.puc.cl.

  17. Laporte JR, Tognoni G. Principios de epidemiología del medicamento. 2a ed. Barcelona: Masson-Salvat Medicina; 2006.

  18. Rodríguez O, Yera IB, Alonso L, García AJ, Debesa F. Descripción de la información que le brinda el médico al paciente durante el acto de prescripción en Marianao, Cuba. Boletín Fármacos. 2008;11(1):68-74.

  19. Lindquist M. seeing and observing in international pharmacovigilance. Achievements and prospects in worldwide drug safety. Sweden: The Uppsala Monitoring Centre; Viewpoint. Watching for safer medicines. The scientific and technical story. Part 2. Gynebra: WHO; 2008.

  20. Debesa F, Jiménez G, Pérez J, Ávila J. La estrategia de farmacoepidemiología en Cuba. Características y papel de la unidad coordinadora de farmacovigilancia en Cuba. Boletines Fármaco. 2007;4(2):67-77.

  21. Magaldi L, Alvis J, Correa D. Farmacovigilancia de los Agonistas Adrenérgicos en pacientes de la unidad de cuidados intensivos del hospital "Dr. Miguel Pérez. Arch Ven Farm Ter. 2004;23(1):23-35.

  22. Naranjo CA, Busto VE. Reacciones adversa a medicamentos. En: Naranjo CA, Busto VE, editores. Métodos en Farmacología Clínica. Washington: Oficina Regional de la OMS; 1992.p.334-50.

  23. Jiménez G, Debesa F, González B, Ávila J, Pérez J. El sistema cubano de farmacovigilancia, seis años de experiencia en la detección de efectos adversos. Rev Cubana Farm [Internet]. 2006 Ene-Abr [citado 12 Oct 2010];40(1):[aprox. 10 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152006000100002&lng=es&nrm=iso&tlng=es




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