González VEM, Revé SLG, Betancourt RMC

Language: Spanish
References: 19
Page: 1585-1594
PDF size: 186.95 Kb.

ABSTRACT

Background: anemia of chronic disease or chronic processes is a multifactorial disease that often coexists with iron deficiency, because of difficulty in iron reuse. It is the second most common cause of anemia in the world only surpassed by iron deficiency. Objective: to evaluate the behavior of hematological and biochemical variables in both groups to determine their usefulness in the differentiation of both modalities within this type of anemia. Method: qualitative hematological variables were statistically analyzed using chisquared test and as well as the quantitative ones also were studied, to biochemical parameters were applied the test of variance for the comparison of both groups. Linear correlation coefficient was established to compare the determination of serumal iron as dependent variable with hematological and biochemical variables. Results: in the case of biochemical variables there were no degrees of significance in its determination. Although the evaluated sample size was small, in this research was showed the usefulness of a biochemical variable as the determination of the lactic dehydrogenase enzyme and hematological variables to carry out the differentiation between anemia of chronic disease associated with mild or severe iron deficiency and the one no associated with iron deficiency. Conclusions: the result of multiple linear regression analysis of quantitative hematological and biochemical variables demonstrated a high correlation between the decrease of serumal iron and the increase of serumal level of lactic dehydrogenase enzymes. New lines of research should be developed in the coming years to clarify situations related to diagnostic differentiation of various clinical diseases, which is essential from the medical point of view, because this determines the therapeutic behavior selection, as in the case of our research.

REFERENCES

1. Bickv RL. Hematology: Clinical and laboratory practice. 3th ed. ST Louis: Mosby; 2009.

2. Brigden ML. Microcytosis in adults: why it is important to consider a spectrum of causes. Lab Med Intern. 2009;15:237.

3. Fernández Rañuda JM. Terapia en Oncohematología. 3ed. Madrid: Editorial Elsevier; 2008.

4. Ponka PF, Beaumont CH, Richardson DJ. Function and regulation of Transferrin and Ferritin. S Hematol. 2009;35:3554.

5. Beguin YL, Clemon GK, Poutrakul PS. Quantitative assesment of erythropoiesis and functional classification of anemia based on measurement of serum transferrine receptor and erythropoietin. Blood. 2009;81:106776.

6. Steigmann O. Uso clínico de la eritropoyetina y otros factores hematopoyéticos en Oncohematología. 3 ed. Madrid: Editorial Elsevier; 2009.

7. Cazzola MS, Beguin YJ. Once weekly epoetin beta is highly effecive in treating anaemic patient with malignancy and defective erythropoietin production. Br J Haematol. 2009;122:38693.

8. Organización Mundial de la Salud. El uso clínico de la sangre. 2 ed. Ginebra: 2009.

9. Morejón M. Las buenas prácticas aplicadas al laboratorio clínico en cuba (CECMED). La Habana: Editorial Sociedades Científicas; 2010.

10. Rodríguez G. Metodología de la Investigación cualitativa. 2 ed. Ciudad de la Habana: Editorial Ciencias Médicas; 2008.

11. Artiles L. Metodología de la investigación para las ciencias de la salud. La Habana: Editorial Ciencias Médicas; 2009.

12. Bayarre H. Estadística Inferencial. 2 ed. La Habana: Editorial Ciencias Médicas; 2008.

13. Estrada del Cueto M. Análisis de algunas variables hematológicas, bioquímicas y clínicas en la anemia drepanocíticas. Resultados preliminares. Rev Cubana Hematol Inmunol Hemoter. 2010 Ago 26; (2):409.

14. Sectorial Provincial de Salud Pública de Camagüey. Registro Provincial de C ánc er . C am agüey : M I N S A P , Departamento de Estadísticas; 2011.

15. Ponka PA. Tissuespecific regulation of iron metabolism and heme synthesis. Distinct control mechanism in erythoid cell. Blood. 2008;89:125.

16. Gambino RF. Elevated serum alkaline phosphatase in liver diseases. Lab Medica. 2009;347:2849.

17. Kato GJ, Mc Gowan V, Machado RF, Little JA, Taylor VI, Gelsin H, et al. Lactate dehydrogenase as a biomarker of anemia. Blood. 2009;107:227985.

18. Wick M, Lehman P. Biochemistry proof in iron metabolism. Diagnosis of anemia. Clinical Haematology. 2009; 36:175992.

19. Sachar DB. Liver diseases and the clinical Laboratory. Clin Chem. 2008;43:8 12.