2012, Number 2
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Medicentro 2012; 16 (2)
Sensitivity and resistance of endemic pathogens in an intensive care unit
Santos PLA, Milián HCG
Language: Spanish
References: 20
Page: 114-121
PDF size: 160.41 Kb.
ABSTRACT
Continuous updating of microbial resistance is necessary to optimize the use of antimicrobials, in
order to achieve maximum effectiveness and minimal morbidity in the treatment of nosocomial
infections. A 1-year prospective study, over the period June 1st 2004 to May 31st, 2005 in the
Intensive Care Unit, at the «Arnaldo Milián Castro» University Hospital in Santa Clara, Villa Clara,
was performed in patients with nosocomial infections, in order to identify the sensitivity and
resistance of isolated endemic pathogens and to introduce recommendations for selecting the
empiric antimicrobial therapy. There was a predominance of staphylococci (before the fourth day)
and of Acinetobacter, Citrobacter and enterobacteria (after the fourth day) in ventilator-associated
pneumonia cases. Also Staphylococcus aureus and enterobacteria Acinetotobacter prevailed in
catheter-related bacteremia. In cases of urinary tract infections associated with urethral catheter,
the level of Pseudomonas was higher. This study provides information that will favorably influence
on the selection of antimicrobial therapy in nosocomial infections in the Intensive Care Unit.
REFERENCES
Álvarez-Lerma F, Sierra CR, Álvarez RL, Rodríguez CO. Política de antibióticos en pacientes críticos. Med Intens. 2010;34(9):600-8.
Alvarez-Lerma F, Olaechea P, Grau S, Marín M, Domínguez A, Martínez-Lanao J, et al. Grupo de Estudio de infección en el paciente crítico (GEIPC-SEIMC). Recomendaciones para la monitorización de antibióticos en pacientes de la UCI. Enferm Infecc Microbiol Clin. 2008;26:230-9.
Márquez RH, Estenoz EJ, Pérez EF, Guinaldo GH. Infección nosocomial en las Unidades de Cuidados Intensivos [CD-ROM]. Ciudad de la Habana; 2002.
Jiménez Guerra SD, Restoy Chantez GA. Comportamiento microbiológico de pacientes con neumonía asociada al ventilador. Rev Cubana Med Intens Emergencias [Internet]. 2007 [citado 12 jun. 2009];6(1):[aprox. 5 p.]. Disponible en: http://bvs.sld.cu/revistas/mie/vol6_1_07/mie02107.htm
Álvarez-Lerma F. Estudio de vigilancia de infección nosocomial en unidades de cuidados intensivos. Informe del año 2001. Med Intens. 2003;27(1):13-23.
Palomar M, Alvarez-Lerma F, Olaechea P, Sierra R, Cerda E; Grupo de Estudio de infección en el paciente crítico. Evolución de la etiología de la infección nosocomial adquirida en UTI. ENVIN 1994-2000. Med Intens. 2001;25(Supl.1):72-6.
Gundián González-Piñera J, Turrent Figueras J, Bastanzuri Pagés M, Suárez Sarmiento E. Control de la infección del torrente sanguíneo en una unidad de cuidados intensivos. Rev Cubana Med Intens Emergencias [Internet]. 2006 [citado 15 jun. 2008];5(4):[aprox. 6 p.]. Disponible en: http://bvs.sld.cu/revistas/mie/vol5_4_06/mie09406.htm
Kevin Lauplan B. Intensive care unit acquired urinary tract infection in a regional critical care system. Infect Control Hosp Epidemiol. Apr. 2005.
Souli M, Galani I, Giamarellou H. Emergence of extensively drug-resistant and pandrugresistant Gram-negative bacilli in Europe. Eurosurveillance [Internet]. 2008 [citado 5 jul. 2009];13(47):[aprox. 6 p.]. Disponible en: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19045
Cantón R, Cobo J. Consumo de antimicrobianos y resistencia en el hospital: una relación difícil de medir y compleja de interpretar. Enferm Infecc Microbiol Clín. 2009;27:437–40.
Ambrose PG. Monte Carlo simulation in the evaluation of susceptibility breakpoints: Predicting the future: Insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy. 2006;26:129-34.
Turnidge J, Paterson DL. Setting and revising antibacterial susceptibility breakpoints. Clin Microbiol Rev. 2007;20:391-408.
Alós JI, Rodríguez-Baño J. ¿Qué antibióticos debemos informar en el antibiograma y cómo? Enferm Infecc Microbiol Clín. 2010;28(10):737-41.
Nemec A, Krizova L, Maixnerova M, Diancourt L, van der Reijden TJ, Brisse S, et al. Emergence of carbapenem resistance in Acinetobacter baumannii in the Czech Republic is associated with the spread of multidrug-resistant strains of European clone II. J Antimicrob Chemother. 2008;62(3):484-9.
Souli M, Kontopidou FV, Koratzanis E, Antoniadou A, Giannitsioti E, Evangelopoulou P, et al. In vitro activity of tigecycline against multiple-drug-resistant, including pan-resistant, gramnegative and gram-positive clinical isolates from Greek hospitals. Antimicrob Agents Chemother. 2006;50(9):3166-9.
Giamarellou H. Colistin: the loss of the last frontier? APUA Newsletter. 2007;25(2):5.
Matthaiou DK, Michalopoulos A, Rafailidis PI, Karageorgopoulos DE, Papaioannou V, Ntani G, et al. Risk factors associated with the isolation of colistin-resistant gram-negative bacteria: a matched case-control study. Critical Care Med. 2008;36(3):807-11.
Gales AC, Jones RN, Sader HS. Global assessment of the antimicrobial activity of polymyxin B against 54731 clinical isolates of Gram-negative bacilli: report from the SENTRY antimicrobial surveillance programme (2001-2004). Clin Microbiol Infect. 2006;12(4):315021.
Georges B, Conil JM, Dubouix A, Archambaud M, Bonnet E, Saivin S, et al. Risk of emergence of Pseudomonas aeruginosa resistance to beta-lactam antibiotics in intensive care units. Crit Care Med. 2006;34(6):1636-41.
Falagas ME, Karageorgopoulos DE. Pandrug resistance (PDR), extensive drug resistance (XDR), and multidrug resistance (MDR) among Gram-negative bacilli: need for international harmonization in terminology. Clin Infect Dis. 2008;46(7):1121-2.