medigraphic.com
ISSN 1029-3043 (Electronic)

2012, Number 1

Next >>

Medicentro 2012; 16 (1)

Treatment of recurrent aphthous stomatitis

Pérez AMM, Rodríguez PA

Language: Spanish
References: 49
Page: 1-10
PDF size: 102.42 Kb.


ABSTRACT

Aphthous stomatitis is one of the most common oral mucosal diseases, occupying the second place. Recurrent aphthous stomatitis is considered a multifactorial disease. Consequently, many therapeutic interventions have been tested, so that, we decided to conduct this study in order to update the knowledge primary care professionals should have about the treatments to be applied by them. These include: glucocorticoids, antimicrobics, antiseptics, antifungal, analgesics, antiinflammatories, local anesthetics, alkaline mouthwash, immunomodulators, immunosuppressants, drugs to reduce stress, nutritional supplements, antiparasitics, antihistaminics, cytoprotectives, laser radiation, pentoxifylline, colchicine, chloroquine, estrogens, phytotherapy, levamisole, acupuncture, digitopuncture, auriculopuncture, propolis, homeopathy, antiviral drugs, lysozyme, cromolyn sodium (Intal), zinc sulfate, sulfone, nonspecific immunoglobulins, debacterol, dalargin, plasmapheresis, cellulose bioadhesive patch, shark liver oil, dapsone, low density ultrasound, rebamipide, amlexanox, nicotine replacement therapies, hyaluronic acid, lactic acid, silver nitrate and a diet free of gluten.


REFERENCES

  1. Llanes Llanes E, Del Valle Portilla MC, Rodríguez Méndez G, Almarales Sierra C, Ysasi Cruz MA, Álvarez Pérez MC, et al. Guías Prácticas de enfermedades gingivales y periodontales. En: Sosa Rosales MC. Guías Prácticas de Estomatología. La Habana: MINSAP; 2003. p. 210-3.

  2. Chinea Meneses EM, De la Rosa Samper H, Morales Aguiar DR. Etiología y patogenia de las enfermedades periodontales agudas y crónicas. En: Chinea Meneses EM, González Díaz ME, editores. Compendio de Periodoncia. La Habana: Ciencias Médicas; 2006. p. 165-6.

  3. Chinea Meneses EM, González Díaz ME, editores. Diagnóstico, pronóstico y tratamiento de la enfermedad periodontal inflamatoria aguda. En: Compendio de Periodoncia. La Habana: Ciencias Médicas; 2006. p. 187-91.

  4. Doncel Pérez C, Martínez Pérez M, López Ilizástigui A, Ilizástigui Ortueta ZT. Comportamiento epidemiológico de la estomatitis aftosa recurrente en pacientes del Instituto Superior de Medicina Militar "Dr. Luis Díaz Soto", 2007. Rev Cubana Med Mil [Internet]. 2009 jun. [citado 17 mar. 2011];38(2):[aprox. 6 p.]. Disponible en: http://wwww.scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138- 65572009000200004&lng=es

  5. Pacho Saavedra JA, Piñol Jiménez FN. Estomatitis aftosa recurrente. Actualización. Rev Cubana Estomatol [Internet]. 2005 abr. [citado 23 mar. 2011];42(1):[aprox. 3 p.]. Disponible en: http://www.scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072005000100006&lng=es

  6. Muniz Alves P, da Silva Ramalho L, Souza de Oliveira R, Leite Cavalcanti A, Guedes Queiroz LM. Fatores de risco da ulceração aftosa recorrente: uma revisão dos achados atuais. Rev Ciênc Méd Biol [Internet]. 2008;7(1):[citado 8 feb. 2008]. Disponible en: http://www.portalseer.ufba.br/index.php/cmbio/article/view/4361/3183

  7. Wilhelmsen NS, Weber R, Monteiro F, Kalil J, Miziara ID. Correlation between histocompatibility antigens and recurrent aphthous stomatitis in the brazilian population / Estudo da associação entre antígenos de histocompatibilidade e estomatite aftoide recorrente em população brasileira. Braz J Otorhinolaryngol. 2009 Mayo-Jun. [citado 17 abr. 2010];75(3):[aprox. 5 p.]. Disponible en: http://www.scielo.br/pdf/bjorl/v75n3/pt_v75n3a19.pdf

  8. Faleh AS. Does smoking really protect from recurrent aphthous stomatitis? Ther Clin Risk Manag. 2010;(6):573–7. PMCID: PMC2999509

  9. Bellón Leyva S, Echarry Cano O. Evaluación clínica de la efectividad de bórax en el tratamiento de la estomatitis aftosa. Rev Cubana Estomatol [Internet]. 2006 jun. [citado 17 mar. 2011];43(2):[aprox. 3 p.]. Disponible en: http://www.scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072006000200006&lng=es

  10. Castillo Castillo A, Pérez Borrego A, Guntiñas Zamora MV. Uso del inmunoferón en el tratamiento de la estomatitis aftosa recurrente en niños. Rev Cubana Estomatol [Internet]. 2006 [citado 17 mar. 2011];43(3):[aprox. 6 p.]. Disponible en: http://www.bvs.sld.cu/revistas/est/vol43_3_06/est05306.htm

  11. Sunitha M, Shanmugam S. Evaluation of salivary nitric oxide levels in oral mucosal diseases: A controlled clinical trial. Indian J Dent Res [Internet]. 2006 jul.-sep. [citado 23 mar. 2010];17(3):[aprox. 6 p.]. Disponible en: http://www.ijdr.in/text.asp?2006/17/3/117/29878

  12. Sciubba JJ. Oral mucosal diseases in the office setting--part I: Aphthous stomatitis and herpes simplex infections. Gen Dent. 2007 abr.;55(4):347-54. PubMed PMID: 17682646

  13. Demetriades N, Hanford H, Laskarides C. General manifestations of Behçet's syndrome and the success of CO2-laser. as treatment for oral lesions: a review of the literature and case presentation. J Mass Dent Soc. 2009;58(3):24-7. PubMed PMID: 19927952.

  14. De Barros Gallo C, Martins Mimura MA, Nobuo Sugaya N. Psychological stress and recurrent aphthous stomatitis. Clinics [Internet]. 2009 [citado 17 mar. 2010];64(7):[aprox. 6 p]. Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807- 59322009000700007&lng59322009000700007

  15. Ramin S, Farhad Z, Rasoul S, Afsaneh A, Mehdi M, Fereydoun D, et al. Gluten sensitivity enteropathy in patients with recurrent aphthous stomatitis. BMC Gastroenterol [Internet]. 2009 [citado 15 sep. 2010];9(44):[aprox. 8 p.]. Disponible en: http://www.biomedcentral.com/1471- 230X/9/44

  16. Vucicevic Boras V, Savage NW. Recurrent aphthous ulcerative disease: presentation and management. Aust Dent J. 2007;52(1):10-5. PubMed PMID: 00459; PubMed Central PMCID: PMC. 183478.

  17. Miziara ID, Costa KC, Mahmoud A, Weber R, Wilhelmsen NS, Imamura R. Laryngeal manifestations in atypical recurrent aphthous stomatitis / Manifestações laríngeas da Estomatite Aftoide Recorrente Atípica. Braz J Otorhinolaryngol [Internet]. 2009 sep.-oct. [citado 17 mar. 2011];75(5): [aprox. 6 p]. Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942009000500008&lng=en

  18. Pérez Ángel MM. Algoritmo para una conducta integral en los pacientes con estomatitis aftosa recurrente [TESIS]. Instituto Superior de Ciencias Médicas Dr. Serafín Ruiz de Zárate Ruiz de Villa Clara. Facultad de Estomatología; 2008.

  19. Bellón Leyva S, Calzadilla Mesa XM. Efectividad del uso del propóleo en el tratamiento de la estomatitis aftosa. Rev Cubana Estomatol [Internet]. 2007 sep. [citado 17 mar. 2011];44(3):[aprox. 4 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072007000300008&lng=es

  20. Watashi Hirata CH, Caluta Abranches D, Martins Mimura MA, Oliveira Lima E, Maurice Weckx LL. Ulceração aftosa recorrente no Ambulatório de Estomatologia da UNIFESP. RBM Rev Bras Med [Internet]. 2010 [citado 8 oct. 2009]. Disponible en: http://www.moreirajr.com.br/revistas.asp?fase=r003&id_materia=4216

  21. Hello M, Barbarot S, Bastuji-Garin S, Revuz J, Chosidow O. Use of thalidomide for severe recurrent aphthous stomatitis: a multicenter cohort analysis. Medicine (Baltimore). 2010 Mayo;89(3):176-82. PubMed PMID: 20453604

  22. Pereira Karuza MA, Rocha Danielle AP, Hébel Galbao C, Freitas RA. Ulceração aftosa recorrente: revisão dos conceitos atuais. Rev Odontol UNESP [Internet]. 2006 jan.-mar. [citado 19 nov. 2010];35(1):[aprox. 8 p.]. Disponible en: http://rou.hostcentral.com.br/PDF/v35n1a09.pdf

  23. Chuang P, Langone AJ. Clobetasol ameliorates aphthous ulceration in renal transplant patients on sirolimus. Am J Transplant [Internet]. 2007 [citado 23 mar. 2010];7(3):[aprox. 3 p.]. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/j.1600-6143.2006.01678.x/pdf

  24. Hamazaki K, Itomura M, Hamazaki T, Sawazaki S. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial. Nutrition. 2006;22(5):534-8. PubMed PMID: 16472981

  25. Wehba Ch, Fernandes F, Oppi EC. Application of the ointment base of chamomile extract as adjunctive in reducing symptoms of the painful, ulcerated lesions of the oral mucosa. RBM [Internet]. 2008 jun. [citado 9 oct. 2008]. 65(5):[aprox. 3 p.]. Disponible en: http://www.moreirajr.com.br/revistas.asp?fase=r003&id_materia=3761

  26. Miziara ID. O tratamento da estomatite aftóide recorrente ainda intriga: Rev Assoc Med Bras [Internet]. 2009 [citado 23 mar. 2010];55(2):[aprox. 3 p.]. Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302009000200001&lng=en

  27. Nanke Y, Kamatani N, Okamoto T, Ogiuchi H, Kotake S. Irsogladine is effective for recurrent oral ulcers in patients with Behçet's disease: an open-label, single-centre study. Drugs R D [Internet]. 2008 [citado 2 mar. 2010];9(6):[aprox. 3 p.]. Disponible en: http://www.ingentaconnect.com/content/adis/rdd/2008/00000009/00000006/art00008

  28. Boldo A. Major recurrent aphthous ulceration: Case report and review of the literature. Conn Med. 2008 Mayo;72(5):271-3. PubMed PMID: 18593062

  29. Martins Mimura MA, Kenji Hirota S, Nobuo Sugaya N, Sanches Jr JA, Migliari, Dante A. Systemic treatment in severe cases of recurrent aphthous stomatitis: an open trial. Clinics [Internet]. 2009 Mar. [citado 23 mar. 2010];64(3):[aprox. 3 p.]. Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322009000300008&lng=en

  30. Femiano F, Lanza A, Buonaiuto C, Gombos F, Nunziata M, Piccolo S, et al. Guidelines for diagnosis and management of aphthous stomatitis. Pediatr Infect Dis J. 2007;26(8):728-32. PubMed PMID:17848886

  31. Gorsky M, Epstein J, Rabenstein S, Elishoov H, Yarom N. Topical minocycline and tetracycline rinses in treatment of recurrent aphthous stomatitis: a randomized cross-over study. Dermatol Online J. 2007 Mayo 1ro;13(2):1-4. PubMed PMID 17498420.

  32. Preshaw PM, Grainger P, Bradshaw MH, Mohammad AR, Powala CV, Nolan A. Subantimicrobial dose doxycycline in the treatment of recurrent oral aphthous ulceration: a pilot study. J Oral Pathol Med. 2007 Abr.;36(4):236-40. PubMed PMID: 17391302.

  33. Zhou Y, Chen Q, Meng W, Jiang L, Wang Z, Liu J, et. al. Evaluation of penicillin G potassium troches in the treatment of minor recurrent aphthous ulceration in a Chinese cohort: a randomized, double-blinded, placebo and no-treatment-controlled, multicenter clinical trial. Oral Med. 2010 Apr.;109(4):561-6. PubMed PMID: 20188604.

  34. Ministerio de Salud Pública. Centro para el desarrollo de la Farmacoepidemiología. Formulario Nacional de Medicamentos. La Habana: Ecimed; 2006. p. 368-70.

  35. Paghdal KV, Schwartz R. Thalidomide and its dermatologic uses. Acta Dermatovenerol Croat. 2007;15(1):39-44. PubMed PMID: 17433179.

  36. Weckx Luc L, Hirata C, Huatas H, Abreu M, Milanez Morgado de A, Fillizolla Ciorla V,et al. Levamisole does not prevent lesions of recurrent aphthous stomatitis: a double-blind placebocontrolled clinical trial. Rev Assoc. Med Bras. [Internet]. 2009 [citado Mar 23 2010]; 55(2) [ aprox. 3 p.]: Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104- 42302009000200014&lng=en

  37. Barroso Palomino M. Utilización del adhesive tisular tisuacryl en Estomatología. Revisión bibliográfica. Rev Cubana Estomatol. [Internet]. 2005 Dic [citado Mar 23 2010];42(3): [aprox. 3 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75072005000300006&lng=es

  38. Arabaci T, Kara C, Ciçek Y. Relationship between periodontal parameters and Behçet's disease and evaluation of different treatments for oral recurrent aphthous stomatitis. J Periodontal Res. 2009 Dec.;44(6):718-25. PubMed PMID: 19076988.

  39. Montero SR, Ferrari Tonani PC. O uso do apontador laser no tratamento da afta bucal treatment of the oral aphthous ulcer. Rev Assoc Paul Cir Dent. 2007 nov.-dez.;61(6):434-8.

  40. Minelli L, Airton dos Santos G, Siega FR. Pentoxifilina em Dermatologia .The use of pentyoxifilin in dermatological diseases. RBM Rev Bras Med. 2006 jun.;63(6):278-82.

  41. Thornhill MH, Baccaglini L, Theaker E, Pemberton MN. A randomized, double-blind, placebocontrolled trial of pentoxifylline for the treatment of recurrent aphthous stomatitis. Arch Dermatol [Internet]. 2007 [citado 2 feb. 2010]; 143(4):[aprox. 3 p.]. Disponible en: http://archderm.amaassn. org/cgi/content/full/143/4/463

  42. López Hernández OD, Torres Amaro L, Salomón Izquierdo S, González Sanabia ML, Chávez Figueredo D. Secado por aspersión de extracto acuoso de Bidens alba L a escalas de laboratorio y banco. Rev Cubana Plantas Med [Internet]. 2008 sep.-dic. [citado 2 feb. 2011];13(4):[aprox. 6 p.]. Disponible en: http://bvs.sld.cu/revistas/pla/vol13_4_08/pla10408.htm

  43. Shrivastava R, John GW. Treatment of Aphthous Stomatitis with topical Alchemilla vulgaris in glycerine. Clin Drug Investig [Internet]. 2006;26(10): [aprox. 5 p.]. Disponible en: http://www.ingentaconnect.com/content/adis/cdi/2006/00000026/00000010/art00003

  44. Samet N, Laurent C, Susarla SM, Samet-Rubinsteen N. The effect of bee propolis on recurrent aphthous stomatitis: a pilot study. Clin Oral Investig [Internet]. 2007 [citado 2 ene. 2011 ];11(2):[ aprox. 6 p.]. Disponible en: http://resources.metapress.com/pdfpreview. axd?code=d86t80r42n865358&size=largest

  45. Mousavi F, Mojaver YN, Asadzadeh M, Mirzazadeh M. Homeopathic treatment of minor aphthous ulcer: a randomized, placebo-controlled clinical trial. Homeopathy. 2009 Jul.;98(3):137-41. PubMed PMID: 19647206.

  46. Liu J, Zeng X, Chen Q, Cai Y, Chen F. An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial. Oral Med. 2006;102(4):475-81. PubMed PMID: 16997114.

  47. Marakoglu K, Sezer RE, Toker HC, Marakoglu I. The recurrent aphthous stomatitis frequency in the smoking cessation people. Clin Oral Investig [Internet]. 2007 [citado 3 feb. 2010 ];11(2):[aprox. 1 p.]. Disponible en: http://www.springerlink.com/content/742305ut31556041/

  48. Nolan A, Baillie C, Badminton J, Rudralingham M, Seymour RA. The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration. J Oral Pathol Med. 2006;35(8):461-5. PubMed PMID: 16918596.

  49. Sharquie KE, Al-Tammimy SM, Al-Mashhadani S, Hayani RK, Al-Nuaimy AA. Lactic acid 5 percent mouthwash is an effective mode of therapy in treatment of recurrent aphthous ulcerations. Dermatol Online J. 2006 Dec. 10;12(7):2-5. PubMed PMID: 17459288.




2020     |     www.medigraphic.com