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Órgano Oficial del Instituto de Ciencias de la Salud, Hospital Escuela y Facultad de Medicina-Xalapa

2012, Number 1

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Rev Med UV 2012; 12 (1)

Hormonal profile violence and suicide: exploratory study

Pérez-Vásquez MO, Gutiérrez-García AG, Contreras CM, López-Amador N

Language: Spanish
References: 62
Page: 6-13
PDF size: 512.13 Kb.


ABSTRACT

Introduction. Suicide is a major cause of death with some differences by gender. The lower female and the higher male predisposition to commit suicide suggests some participation of gonadal hormones. Herein, testosterone seems to influence impulsivity, while progesterone and estradiol exert anxiolytic and antidepressant actions, however, the relationship between these hormones and violence is a controversial issue. Objective. We compared serum testosterone, progesterone and estradiol in three male groups: victims of suicide, deceased by violent means, and matched-healthy living controls. Materials and methods. Testosterone was determined by enzyme linked immuno assay (ELISA) and progesterone and estradiol by microparticle enzyme immunoassay (MEIA). Results. The hormonal profile indicated that serum testosterone levels were significantly [F2, 30 = 5.28, p ‹ 0.01] higher in suicide (8.5 ± 1.30 ng/mL) than deceased by violent means group (2.3 ± 1.54 ng/mL) and controls alive (4.5 ± 0.98 ng/mL), without significant differences between the last two groups. Serum level of estradiol was the highest in the suicide group (92.6 ± 16.21 pg/mL), intermediate in controls (45.0 ± 3.10 pg/mL) [F2 , 31 = 5.16, p ‹ 0.001] and lowest in those deceased by violent means (13.5 ± 3.04 pg/mL). No differences among groups were detected in serum levels of progesterone [F2, 31 = 0.81, p = 0.45]. Conclusions. Suicide could be characterized by high levels of estradiol and testosterone, which could be related to a high degree of impulsivity.


REFERENCES

  1. World report on violence and health. World Health Organization. Edited by Krug EG, et al. 2002.

  2. Gutiérrez-García AG, Contreras CM, Orozco-Rodríguez CHR. El suicidio, conceptos actuales. Salud Mental 2006; 29(5): 66-74.

  3. Sharma BR, Sharma A, Bano S. A global public health concern. J Chin Clin Med 2009; 4(6): 353-360.

  4. Gutierrez-García AG, Contreras CM y Orozco-Rodríguez CHR. El suicidio y algunos de sus correlatos neurobiológicos. Primera Parte. Salud Mental 2008; 31(004):321-330.

  5. Giupponi G, et al. Socioeconomic risk factor and depressive symptoms in alcohol use disorders among male suicides in south Tirol, Italy. J Addict Dis 2010; 29:466-474.

  6. Krysinska K y Lester D. Post-traumatic stress disorder and suicide risk: a systematic review. Arch Suicide Res 2010; 14:1-23.

  7. Novick DM, Swartz HA y Frank E. Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence. Bipolar Disord 2010; 12:1-9.

  8. Jimenez-Treviño L, et al. Endotipos y conductas suicidas. Actas Esp Psiquiatr 2011; 39(1):61-69.

  9. Pelkonen M, Karlsson L y Marttunen M. Adolescent suicide: epidemiology, psychological theories, risk factors and prevention. Curr Pediatr Rev 2011; 7:52-67.

  10. Heeringen K. The neurobiology of suicide and suicidality. Can J Psychiatry 2003; 48(5): 292-300.

  11. Gos T, et al. Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patients. Eur Arch Psychiatry Clin Neurosci 2008; 258: 513-520.

  12. Ajdacic-Gross V, et al. Methods of suicide: international suicide patterns derived from the WHO mortality database. Bull World Health Organ 2008; 86(9): 726-732.

  13. Borges G, Orozco R, Benjet C, Medina-Mora ME. Suicidio y conductas suicidas en México: retrospectiva y situación actual. Salud Pública 2010; 52: 292-304.

  14. Reynolds CF, Kupfer DJ. Depression and aging: a look to the future. Psychiatr Serv 1999; 50(9):1167-1172.

  15. Schweiger U, et al. Testosterone, gonadotrophin and cortisol secretion in male patients with major depression. Psychosom Med 1999; 61(3): 292-296.

  16. Tripodianakis J, Markianos M, Rouvali O, Istikoglou C. Gonadal axis hormones in psychiatric male patients after a suicide attempt. Eur Arch Psychiatry Clin Neurosci 2007; 257: 135–139.

  17. Olweus D, Mattsson A, Schalling D, Low H. Testosterone, aggression, physical and personality dimensions in normal adolescent males. Phychosom Med 1980; 42(2): 253-269.

  18. Higley J, et al. CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors. Biol Psychiatry 1997; 42(4): 305-307.

  19. Liu J, Wuerker A. Biosocial bases of aggressive and violent behaviorimplications for nursing studies. Int J Nurs Stud 2005; 42(2): 229-241.

  20. Sánchez J, et al. Female preschool children. Psychoendocrinology 2000; 25: 773-783.

  21. Joshi D, et al. Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men. Clin Endocrinol 2010; 72: 232-240.

  22. Giammanco M, et al. Testosterone and aggressiveness. Med Sci Monit 2005; 11(4): 136-145.

  23. Mehta PH, Beer J. Neural mechanism of the testosterone-aggression relation: the role of orbitofrontal cortex. J Cogn Neurosci 2009; 22(10): 2357-2368.

  24. Picazo O, Fernández-Guasti A. Anti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior test. Brain Res 1985; 680: 135-141.

  25. Frye CA, et al. Progesterone´s effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors. Psychopharmacology 2006; 86: 312-322.

  26. Contreras CM, et al. Timig of progesterone and allopregnanolone effects in a serial forced swim test. Salud Mental 2011; 34: 309-314.

  27. Schneider J, et al. Progesterone receptors mediate male aggression toward infants. PNAS 2003; 100(5): 2951-2956.

  28. Walf AA, Frye CA. A review and update of mechanisms of estrogen in the hippocampus and amygdale for anxiety and depression behavior. Neuropsychopharmacology 2006; 31: 1097-1111.

  29. Rissman EF. Roles of oestrogen receptors α and β in behavioural neuroendocrinology: beyond yin/yang. J Neuroendocrinol 2008; 20: 873-879.

  30. Walf AA. Oestrogen receptor β is involved in the actions of oestrogens in the brain for affective behaviour, but not trophic effects in peripheral tissues. J Neuroendocrinol 2010; 22: 141-151.

  31. Parry BL. Manejo óptimo de la depresión perimenopaúsica. Revista del Climaterio 2011; 15(85): 26-36.

  32. Finkelstein JW, et al. Estrogen or testosterone increased self-reported aggressive behaviors in hipogonadal adolescents. J Clin Endocrinol Metab 1997; 82(8): 2433-2438.

  33. Trainor BC, Greiwe KM, Nelson RJ. Individual differences in estrogen receptor α in select brain nuclei are associated with individual differences in aggression. Horm Behav 2006; 50: 338-345.

  34. Trainor BC, Kyomen HH, Marier CA. Estrogenic encounters: how interactions between aromatase and the environment module aggression. Front Neuroendocrinol 2006; 27(2): 170-179.

  35. Gustavsson G, Traskman-Bendz L, Higley JD, Westrin A. CSF testosterone in 43 male suicide attempters. Eur Neuropsychopharmacol 2003; 13: 105–109.

  36. Butterfield M, et al. Neuroactive steroids and suicidality in posttraumatic stress disorder. Am J Psychiatry 2005; 162(2): 380-382.

  37. Pérez-Rodríguez MM, et al. Lack of association between testosterone and suicide attempts. Neuropsychobiology 2011; 63: 125-130.

  38. Lazarou S, Reyes-Vallejo L, Morgentaler A. Wide variability in laboratory reference values for serum testosterone. J Sex Med 2006; 3: 1085-1089.

  39. Wilson DH, et al. Rapid, automated assay for progesterone on the Abbott AxSYMTM analyzer. Clin Chem 1998; 1: 86-91.

  40. Abbot Laboratories. Estradiol, Abbot Axsym System. 66-8977/R1. U.S.A. 1997.

  41. George DT, et al. Serotonin, testosterone and alcohol in the etiology of domestic violence. Psychiatry Res 2001; 104: 27–37.

  42. Virkkunen M, et al. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 1994; 51: 20-27.

  43. Garcia-Segura LM. Aromatase in the brain: not just for reproduction anymore. J Neuroendocrinol 2008; 20: 705-712.

  44. Czajka-Oraniec I, Simpson ER. Aromatase research and its clinical significance. Endokrinol Pol 2010; 61(1): 126-134.

  45. Toda K, et al. A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19). J Endocrinol 2001; 168: 217-220.

  46. Everett JW. Pituitary and hypothalamus: perspectives and overview. Knobil y Neill´s. Physiology of Reproduction. Chapter 26, Volume 1. 3th ed. Academic Press, 2006, pp 1447-1450.

  47. Baca-García E, Diaz-Sastre C, De Leon J, Saiz-Ruiz J. The relationship between menstrual cycle phases and suicide attempts. Psychosom Med 2000; 62: 50–60.

  48. Baca-García E, et al. Association between the menses and suicide attempts: a replication study. Psychosom Med 2003; 65: 237–244.

  49. Baca-García E, et al. A pilot study on a gene-hormone interaction in female suicide attempts. Eur Arch Psychiatry Clin Neurosci 2003; 253: 281–285.

  50. Fourestié V, et al. Suicide attempts in hypo-oestrogenic phases of the menstrual cycle. Lancet 1986; 2(8520): 1357-1360.

  51. Moen MH, Kahn H, Bjerve KS, Halvorsen TB. Menometrorrhagia in the perimenopause is associated with increased serum estradiol. Maturitas 2004; 47(2): 151-155.

  52. DeBattista C, Smith DL, Schatzberg A. Modulation of monoamine neurotransmitters by estrogen: clinical implications. In: Leibenluft E, editor. Gender differences in mood and anxiety disorders. Review of psychiatry. Vol 18. Washington DC: American Psychiatric Press 1999;137–160.

  53. Engström G, Persson B, Levander S. Temperament traits in male suicide attempters and violent offenders. Eur Psychiatry 1999; 14: 278–283.

  54. Campusano MC, et al. Comparación de distintos métodos para evaluar la función androgénica en el adulto mayor. Rev Med Chil 2006; 134: 1123-1128.

  55. Leping Y, Zhi-Jian S, Ren-Shan G. Inhibitors of testosterone biosynthetic and metabolic activation enzymes. Molecules 2011; 16:9983-10001.

  56. Stocco DM, McPhaul MJ. Physiology of testicular steroidogenesis. Knobil y Neill´s. Physiology of Reproduction. Chapter 20, Volume 1. 3th ed. Academic Press, 2006, pp 983.

  57. Gorzalka BB, Caira L. Adrenal mediation of intermale aggression maintained by aromatized and reduced metabolites of testosterone. Aggress Behav 1979; 5:143-154.

  58. Von der Pahlen B, et al. An exploratory study on self-evaluated aggression and androgens in women. Aggress Behav 2002; 28: 273-280.

  59. Von der Pahlen B, Sarkola T, Seppa K, Eriksson CJ. Testosterone, 5 alpha dihydrotestosterone and cortisol in men with and without alcohol-related aggression. J Stud Alcohol 2002; 63(5): 518-526.

  60. Gutiérrez-García AG, Contreras CM, Díaz-Meza JL. Cómo actúa la progesterona sobre el sistema nervioso central. Salud Mental 2000; 23(2): 42-47.

  61. Rodríguez-Landa JF, et al. Allopregnanolone reduces immobility in the forced swimming test and increases the firing rate of lateral septal neurons through actions on the GABAA receptor in the rat. J Psychopharmacol 2007; 21(1): 76-84.

  62. Bitzer J. Progesterone, progestins and psychosomatic health of women. Horm Mol Biol Clin Invest 2010; 3(3): 477-480.




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