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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2012, Number 4

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Rev Esp Med Quir 2012; 17 (4)

Epidemiological characteristics of hereditary breast and ovary cancer in a sample of ISSSTE population

Orozco QM, Cano CS, Gorráez de la MT, Chima GMC, Saavedra LlD

Language: Spanish
References: 20
Page: 291-299
PDF size: 266.06 Kb.


ABSTRACT

Background: Breast cancer in Mexico is the second cause of death (13.3%) and tends to increase. The risk factors related are genetic, age, early menarche and late menopause, overweight and obesity, among others; 5 to 10% of the cases with breast cancer are hereditary.
Objective: To determine the epidemiological characteristics of hereditary breast and ovarian cancer and sporadic breast cancer in a population sample of ISSSTE.
Material and method: We performed a transversal, retrospective, descriptive, and observational study. Clinical records of 137 cases with breast cancer in all clinical stages were reviewed. Hereditary breast and ovarian cancer (HBOC) criteria were used (Colima, Mexico).
Results: 46 cases (33.6%) out of 137 women with breast cancer aged 47 years old in average had criteria for HBOC; 60% were women <50 years old (premenopausal). Breast cancer was more frequent in the Center of Mexico (49.2%), followed by Southern region (31.5%). The average of body mass index (BMI) was 28.6 (from 19.53 to 42.19). Family background of other types of cancer was higher (42%), with predominance of cervical cancer, than breast cancer (22%).
Conclusions: Frequency of HBOC was higher than reported in literature. Obesity is a constant risk factor in breast cancer, with predominance in sporadic breast cancer and postmenopausal women with highest BMI (› 40). Risk factors of HBOC may be influenced; thus, it can have a bearing on morbidity and mortality of this disease.



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