Escobar AJ, Aguirre GJ, Durán MA

Language: Spanish
References: 10
Page: 201-204
PDF size: 141.37 Kb.

ABSTRACT

Congenital hepatic fibrosis (CHF) is an autosomal recessive disease. Its morphological hallmark is the presence of fibrous enlargement of the portal tracts with middle sized bile ducts. This is an immunohistochemical study of the ductal plate and the role in the genesis of CHF. We studies four cases with CHF and histologic slides of liver from embryos of 8, 9 and 10 weeks of gestational age, using immunohistochemical stains (cytokeratin 7, 8, 18, 19 and laminin). The primitive hepatocytes around the portal veins shown ad reactivity for cytokeratin 7, 8, 18, 19 and laminin. The lack of remodelation of the ductal plate results in a persistence of the embryonal bile ducts and the anomalies of the ductal plate may be responsible of congenital diseases of intrahepatic bile ducts including CHF. The results demonstrate that the cells that develop the ductal plate show reactivity for cytokeratin 8, 18, 19 and laminin at the 8th week of gestational age, and this reactivity persists in the bile ducts in the CHF. These findings support the hypothesis that the development of CHF is due to the lack of remodelation of the ductal plate.

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