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2011, Number 4

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Rev Med MD 2011; 2.3 (4)

Yin-Yang of the Nuclear Factor κ B, its role in inflammation, immune response and cancer

Ortiz-Lazareno PC, Lerma-Díaz JM, Domínguez-Rodríguez JR, Hernández-Flores G, Sierra-Díaz E, Bravo-Cuéllar A

Language: Spanish
References: 50
Page: 198-205
PDF size: 629.58 Kb.


ABSTRACT

The Nuclear Factor-κ B (NF-κ B) is an important immunity and swelling regulator, being a key element to the development and progress of malignant tumors. Stimuli such as bacterial products, viral, proinflammatory cytokine and oxidative stress trigger its activation, which unchains the participation of genes involved in the control of the immune response and the inflammatory process. As consequence of the biological activity of this factor, it begins a complex net of organized negative feedback that allows the re-establishment of the homeostasis once the strange agent has been eliminated. The NF-κ B may represent a doubleedged sword, since it is on one hand essential for an adequate immune response to a variety of environmental stress conditions but the increase on its activity can unchain chronic inflammation and cancer. The mechanisms that allow the activation of the NF-κ B are not clear but involve flaws in ways of signaling, mutations or chromosomal rearrangement. This factor has great potential as a therapeutic target for chronic inflammatory diseases and cancer.


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