Roche AC, Ramos VJ, Artiles MD

Language: Spanish
References: 13
Page:
PDF size: 439.01 Kb.

ABSTRACT

The extragonadal appearance of germ cell tumors are an unusual, but not insignificant, presentation of these neoplasms. Almost always close to the midline, they have their highest incidence in the anterior mediastinum and are called, generically, extragonadal mediastinal germ cell tumors. With a favorable response to oncospecific treatment and its appearance in early stages of life, they require an accurate and timely diagnosis. In our institution, it has been possible to diagnose, in less than a year, four cases with different varieties of these tumors. Even in one case the diagnosis was reached with a fine needle aspiration biopsy, and it was confirmed in the biopsy. These cases are presented, as well as a brief overview of these tumors.

REFERENCES

1. Suster SL, Moran C. Mediastinum. En: Weidner N. Modern surgical pathology. Vol 1. 2nd ed. España: Elsevier Imprint; 2009. p. 476-84.

2. Plaza José A, Moran Cesar A, Suster S. Thymus and Mediastinum. En: Gattuso P. Differential diagnosis in surgical pathology. 2nd ed. España: Elsevier Imprint; 2009. p. 301-6.

3. Zavala Elizondo A, Martínez Montelongo R, González JE. Tumor extragonadal de células germinales en mediastino: aportación de un caso. Actas Urol Esp. 2008;32(3):357-9.

4. Moran CA, Suster S. Primary germ cell tumors of the mediastinum. Analysis of 322 cases with special emphasis on teratomatous lesions and anew proposal for histopathologic classification and clinical staging. Cancer. 1997;80:681-90.

5. Dominguez-Malagon H, Cano-Valdez AM, Moran CA, Suster S: Germ cell tumors with sarcomatous components: A clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol. 2007;31:1356-62.

6. McKenney JK, Heerema-McKenney A, Rouse RV. Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. Adv Anat Pathol. 2007;14:69–92.

7. Shinagare Atul B. Jagannathan Jyothi P. Ramaiya Nikhil H. Adult Extragonadal Germ Cell Tumors. Am Roentgen Ray. 2010;195:W274–W80.

8. Mrad K, Abid L, Oubiche F. The value of cytology in the diagnosis of extragonadal germ cell tumors. Ann Pathol. 2004;24(4):356-59.

9. de la Espada V, Shahi PK, Marin BH. Mediastinal Germ-Cell Tumours: An Med Interna. 2008 may;25(5):241-43.

10. 10.Coulier B, Lefebvre Y, de Visscher L. Metastases of clinically occult testicular seminoma mimicking primary extragonadal retroperitoneal germ cell tumors. JBR-BTR. 2008 julaug; 91(4):139-44.

11. 11.Balzer BL, Ulbright TM. Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol. 2006 jul;30(7):858-65.

12. 12.Young RH. Review Testicular tumors--some new and a few perennial problems. Arch Pathol Lab Med. 2008 apr;132(4):548-64.

13. Angulo JC, González J, Rodríguez N. Clinicopathological study of regressed testicular tumors (apparent extragonadal germ cell neoplasms). J Urol. 2009 nov; 182(5):2310.