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2012, Number 3

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Rev Med Inst Mex Seguro Soc 2012; 50 (3)

Pro-inflammatory cytokines related to severity and mortality in type 2 diabetes patients with soft tissue infection

García-Elorriaga G, Padilla-Reyes M, Cruz-Olivo F, Fuentes-Allen JL, Rey-Pineda G, González-Bonilla C

Language: Spanish
References: 25
Page: 237-241
PDF size: 33.83 Kb.


ABSTRACT

Objective: to determine the relation between IL6, IL10 and TNFα serum levels in a cohort of patients with type 2 diabetes (T2D) and severe soft tissue infections (STI), with severity and mortality factors.
Methods: a comparative and transversal study, with 15 adult patients, any gender, with T2D and STI were done. A T2D control group of 20 patients without STI was included. Apache II Score, glycemia and by ELISA, IL6, IL10 and TNFα, were determined.
Results: in all patients, it was a correlation at beginning between glycemia and IL6 (r = 0.67, IC 95 % 0.24 a 0.88), as soon as glycemia and Apache II, (r = 0.59, IC 95 % 0.11 a 0.83).
Conclusions: although IL6 was very usefulness, it is not a routine test in clinical laboratory and it is expensive, but in medical practice, it could be possible to evaluate these patients with Apache II Score and glycemia. However, in STI, the values of IL6 and IL10 were highly significant. It is likely that IL6 is a marker of poor outcome.


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