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Colegio de Medicina Interna de México.

2012, Number 6

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Med Int Mex 2012; 28 (6)

Brain death; axiomatic timely diagnosis and definitive neurological loss

García S, Sauri SS, Meza E, Villagómez AJ

Language: Spanish
References: 45
Page: 585-597
PDF size: 287.95 Kb.


ABSTRACT

Background: The idea of death has changed in the different eras, at moment is accepted that the brain death determines the legal death of a person. In this review we analyzed definition, pathophysiology, clinical criteria and techniques for confirmatory declare brain death.
Material and methods: It was conducted a literature search in the databases of Medline, Pubmed, Artemisa and LILACs from 1980 to 2012, for search were introduced the following words: Guidelines brain death, ancillary testing brain death; in addition it were included classic texts and articles more ancient.
Conclusions: At the present death of the brain is legally accepted as the culmination of the life, the diagnosis of brain death is essentially clinical, ancillary testing are of great help, but by themselves do not establish the diagnosis of brain death. The opportunity of diagnosis will also help the transplant programs should be strengthened.



REFERENCES

  1. Tuttle-Newhall JE, Krishnan SM, Levy MF, McBride V, Orlowski JP, Sung RS Organ donation and utilization in the United States: 1998–2007. Am J Transplant 2009;9:879-893.

  2. Información del Centro Nacional de Trasplantes en relación al estado actual de la donación y trasplante de órganos en México. (Revisado el 29 de agosto de 2012) http://www. cenatra.gob.mx/rnt/Grafica_img_le_2.php).

  3. Baron L, Shemie SD, Teitelbaum J, Doig CJ. Brief review: history, concept and controversies in the neurological determination of death. Can J Anaesth. 2006;53:602-608.

  4. A definition of irreversible coma: Report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain death. JAMA 1968;205:337-40.

  5. Mohandas A, Chou SN. Brain death a clinical and pathological study. J Neurosurg 1971;35:211-218.

  6. Diagnosis of brain death. Statement issued by the honorary secretary of the Conference of Medical Royal Colleges and their Faculties in the United Kingdom on 11 October 1976. Br Med J. 1976;2(6045):1187-1188.

  7. The President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. Defining death. JAMA 1981;246:2184-2186.

  8. Hammer MD, Crippen D. Brain death and withdrawal of support. Surg Clin North Am 2006;86:1541-1551.

  9. Mollaret P, Goulon M. The depassed coma. Rev Neurol (Paris) 1959;101:3-15.

  10. Canadian Neurocritical Care Group. Guidelines for the diagnosis of brain death. Can J Neurol Sci 1999;26(1):64–66.

  11. Wijdicks EFM. Brain death worldwide. Accepted fact but no global consensus in diagnostic criteria. Neurology 2002;58:20-25.

  12. Laureys S, Owen AM, Schiff ND. Brain function in coma, vegetative state, and related disorders. Lancet Neurol. 2004;3:537-546.

  13. Jennett B, Plum F. Persistent vegetative state after brain damage: a syndrome in search of a name. Lancet 1972;1:734-737.

  14. Giacino JT, Ashwal S, Childs N, Cranford R, Jennett B, Katz DI, Kelly JP, Rosenberg JH, Whyte J, Zafonte RD, Zasler ND.The minimally conscious state: definition and diagnostic criteria. Neurology 2002;58:349-353.

  15. Coleman MR, Menon DK, Fryer TD, Pickard JD. Neurometabolic coupling in the vegetative and minimally conscious states: preliminary findings. J Neurol Neurosurg Psychiatry 2005;76:432-434.

  16. Smith E, Delargy M. Locked-in syndrome. BMJ 2005;330:406-409.

  17. Bauer G, Gerstenbrand F, Rumpl E. Varieties of the locked-in syndrome. J Neurol 1979;221:77-91.

  18. Plum F, Posner JB: The Diagnosis of Stupor and Coma. Contemporary Neurology Series 19. Second Edition. Philadelphia, Davis, 1980, pag. 117-128.

  19. López-Navidad A, Caballero FDP. Early diagnosis of brain death in patients treated with central nervous system depressant drugs. Transplantation 2000;70:131-135.

  20. Ivan LP. Spinal reflexes in cerebral death. Neurology 1973;23:650-652.

  21. McNair NL, Meador KL. The ondulating toe flexion sign in brain death. Mov Disord 1992;7:345-347.

  22. Saposnik G, Bueri JA, Mauriño J, Saizar R, Garretto NS. Spontaneous and reflex movements in brain death. Neurology 2000;54:221-223.

  23. The Quality Standards Subcommittee of the American Academy of Neurology. Practice parameters for determining brain death in adults (summary statement). Neurology 1995;45:1012-1014.

  24. Wijdicks EF, Varelas PN, Gronseth GS, Greer DM; American Academy of Neurology. Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2010;74:1911-1918.

  25. Pallis C. ABC of brain stem death. Pitfalls and safeguards. Br Med J (Clin Res Ed) 1982;285:1720-1722.

  26. Grattan-Smith PJ, Butt W. Suppression of brainstem reflexes in barbiturate coma. Arch Dis Child 1993;69(1):151-152.

  27. Chandler JM, Brili RJ. Brainstem encephalitis imitating brain death. Crit Care Med 1991;19:977-979.

  28. Peiffer KM. Brain death and organ procurement. Am J Nurs. 2007;107:58-67; quiz 68.

  29. Arbour R. Clinical management of the organ donor. AACN Clin Issues. 2005;16:551-580

  30. Mascia L, Mastromauro I, Viberti S, Vincenzi M, Zanello M. Management to optimize organ procurement in brain dead donors. Minerva Anestesiol 75:125-133.

  31. Grattan-Smith PJ, Butt W. Suppression of brainstem reflexes in barbiturate coma. Arch Dis Child 1993;69:151-152.

  32. Carpenter MB. Neuroanatomía Fundamentos. 4ta edición Editorial. Ed Médica Panamericana. 1994.

  33. Afifi AK. , Bergman RA. Neuroanatomía funcional: Texto y atlas. 2ª ed. México: McGraw-Hill, 2006

  34. Fustinoni O, Fustinoni JC. Semiología Del Sistema Nervioso: treceava Edición; Editor El Ateneo, 2002

  35. Vaghadia H. Atropine resistance in brain dead organ donors. Anesthesiology 1986;65:711-712.

  36. Power BM, Van Heerden PV. The physiological changes associated with brain death--current concepts and implications for treatment of the brain dead organ donor. Anaesth Intensive Care. 1995;23:26-36.

  37. Sreedhar R, Thomas SV. Brain death and the apnea test. Ann Indian Acad Neurol. 2009;12:201.

  38. Nakagawa TA, Ashwal S, Mathur M, Mysore MR, Bruce D, Conway EE Jr, Duthie SE, Hamrick S, Harrison R, Kline AM, Lebovitz DJ, Madden MA, Montgomery VL, Perlman JM, Rollins N, Shemie SD, Vohra A, Williams-Phillips JA; Society of Critical Care Medicine; Section on Critical Care and Section on Neurology of the American Academy of Pediatrics; Child Neurology Society. Guidelines for the determination of brain death in infants and children: an update of the 1987 Task Force recommendations. Crit Care Med. 2011 ;39:2139-2155.

  39. Beresford HR. Brain death. Neurol Clin. 1999;17:295.

  40. Paniagua-Soto J, Piñero-Benítez M. Muerte encefálica: ¿cuál es el valor diagnóstico de los potenciales evocados multimodales? Med Intensiva 2000;24:124-34.

  41. Monteiro LM, Bollen CW, van Huffelen AC, Ackerstaff RG, Jansen NJ, van Vught AJ. Transcranial Doppler ultrasonography to confirm brain death: a meta-analysis. Intensive Care Med. 2006 ;32:1937-1944.

  42. Orban JC, El-Mahjoub A, Rami L, Jambou P, Ichai C. Transcranial Doppler Shortens the Time Between Clinical Brain Death and Angiographic Confirmation: A Randomized Trial. Transplantation.2012;21:[Epub ahead of print]

  43. Webb A, Samuels O. Brain death dilemmas and the use of ancillary testing. Continuum (Minneap Minn). 2012;18:659-668.

  44. Millán JM, Campollo J. Valor diagnóstico de la angiografía cerebral en confirmación de la muerte encefálica. Ventajas e inconvenientes. Med Intensiva 2000;24:135-141.

  45. Velasco-Suárez M. Responsabilidad científica bioética del neurocirujano. Gac Med Mex 1997;133: 213-219




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