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2001, Number 1

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Rev Med Hosp Gen Mex 2001; 64 (1)

Breast cancer in senescence

Miranda HH, Rivera MNO

Language: Spanish
References: 31
Page: 21-26
PDF size: 59.35 Kb.


ABSTRACT

The incidence of the breast cancer has been increased with the increase in the expectations of the population’s life in general for that the mammary cancer in the senility (that is usually defined as the one that is presented in women that are 65 years old or more), it has increased considerably. The illness meets with more frequency in high social classes and the women of white race are affected to more age that those of black race. When analysing the factors of risk, the American Cancer Society calculates that in some moment of its life, 1 of each 12 women will have the illness and the incidence for the women bigger than 60 years it is of 3 in 1000. Objective: To know the frequency in women bigger than 65 years, clinical stages, treatment varieties and survival. Material and methods: Of 1360 women with breast cancer diagnosed among January from 1990 to January of 1995 were studied in the Unit of Mammary Tumours of the Service of Oncology of the General Hospital of Mexico, 117 patients (8.6%) with diagnostic clinical and histophatology of breast carcinoma and 100 were included with understood ages from 65 to 90 years and with a mean of 71 year-old age, with a classification TNM that corresponded to clinical stage I (2%), clinical stage II (58%) and clinical stage III (30%), they were not classified (10%) to have biopsy to their entrance. The radical surgery was employee in 38% and the conservative with and without radical dissection of the ganglion in armpit 62%. 80% received tamoxifeno before or jointly to other treatments, 34% received radiotherapy pre or postoperative and 18% chemotherapy (FAC or CMF), the half survival to 5 years was of 64%. Conclusion: The incidence in our means is smaller than in the developed countries, the diagnosis, like in the Latin countries, it is made in stages clinical II and III (88%), the treatments conservative and radical surgery, represent the common thing; the hormonotherapy was always indicated and the radiotherapy and the chemotherapy didn’t produce secondary effects when you employment and the treatment should always be individualized.


REFERENCES

  1. Adami H-O, Malker B, Holmberg L et al: The relation between survival and age at diagnosis in breast cancer. N Engl J Med 1986; 315: 559.

  2. Law TM, Hesketh PJ. Breast cancer in elderly women: Presentation, survival, and treatment options. Surg Clin North Am 1996; 76 (2): 289-308.

  3. 2a. Compendio del Registro Histopatológico de Neoplasias en México. Secretaria de Salud, 1996: 33.

  4. Fleming I, Fleming M. Breast Cancer in elderly Women. Cancer 1994 1; 74 (suppl 7): 2160-2164.

  5. 4 Costanza ME. The extent of breast cancer screening in older women. Cancer 1994 1; 74 (suppl 7): 2040-50.

  6. 5 Sener SF. Breast cancer in older woman: Screening and Selection of Locorregional Therapy. Semin Surg Oncol 1996; 21: 328-333.

  7. Miranda HH et al. Factores de riesgo en 1128 mujeres mexicanas con cáncer mamario. Cirugía. Colegio Cirugía General y Gastroenterología 1995; 4: 81-85.

  8. Vital statistics of the United States. US. Public Health Service. Dept of Health and Human Services. NIH Bethesda. Maryland.

  9. Jancik R, Ries L. Cancer in the aged: An epidemiologic perspective on treatment issues. Cancer 1991; 68 (suppl): 2493-2510.

  10. Faulk R, Sickles E, Sollitto R et al: Clinical efficacy of mammography screening in the elderly. Radiology 1995; 194: 193.

  11. Constanza M: Issues in breast cancer screening in older women. Cancer 1994; 74: 2009.

  12. Bondi LA et al. Breast cancer in elderly patients: 65 years of age or older. 9th International Congress on Breast Diseases, 1996.

  13. Muss HB. The role of chemotherapy and adjuvant therapy in the management of breast cancer in older woman. Cancer 1994; 74 (suppl 7): 2165-2171.

  14. Yancik R, Ries LG, Yates JW. Breast cancer in aging women: A population-based study of contrasts in stage, surgery, and survival. Cancer 1989: 976-981.

  15. Berg JW, Hutter RVP: Breast cancer. Cancer 1995; 75: 257.

  16. Kant AK, Glover C, Horm J et al: Does cancer survival differ for older patients? Cancer 1992; 70: 2734.

  17. Ries LAG, Henson DE, Harras A: Survival from Breast Cancer according to tumor and nodal status. Surg Oncol Clin North Am 1994; 3: 35.

  18. Veronesi U, Luini A, Del Vecchio M et al: Radiotherapy after breast-preservation surgery in women with localized cancer of the breast. N Engl J Med 1993; 328: 1587.

  19. Davis S, Karrer F, Moor B et al: Characteristics of breast cancer in women over 80 years of age. Am J Surg 1985; 150: 655.

  20. Maher M, Campana F, Mosseri V et al: Breast cancer in elderly women: A retrospective analysis of combined treatment with tamoxifen and once-weekly irradiation. Int J radiat Oncol Biol Phys 1995; 31: 783

  21. Early Breast Cancer Trialists´ Collaborative Group: Systemic treatment of early breast cancer by hormonal, citotoxic, or immune therapy. Lancet 1992; 399: 1.

  22. Bernardo G, Plastina B, Strada M et al: Breast cancer in elderly patients: our experience about some features. Ann Oncol 1994; 5 (suppl 8): 59.

  23. Harris J, Morrow M, Bonadonna G: Cancer of the breast. In: DeVita V, Hellman S, Rosenberg S (eds): Cancer: Principles and practice of oncology. 4th ed. Philadelphia: JB Lippincott, 1993; 1264.

  24. Jaiyesimi I, Buzdar A, Decker D et al: Use of tamoxifen for breast cancer: Twenty-eight years later. J Clin Oncol 1995; 13: 513.

  25. Norton L: Salvage chemotherapy of breast cancer. Semin Oncol 1994; 21 (suppl 7): 19.

  26. Cianti C. Therapy of breast carcinoma in elderly woman. Clin Ter 1998; 149 (6): 439-446.

  27. Christman J, Muss HB, Case LD et al: Chemotherapy of metastatic breast cancer in the elderly: The Peidmont Oncology Association experience. JAMA 1992; 268: 57.

  28. Wanebo HJ, Cole B. Is surgical management compromised in elderly patients with breast cancer? Ann Surg 1997; 225: 579-589.

  29. Busch E, Kemeny M. Patterns of breast cancer care in the elderly. Cancer 1996; 78 (1): 101-11.

  30. Martin LM, le Pechoux C. Management of breast cancer in the elderly. Eur J Cancer 1994; 30 A: 590-596.

  31. Fowble B. An Assessment of treatment options for breast conservation in the elderly woman with early stage breast cancer. Int J Radiation Oncology Biol Phys 1995; 31 (4): 1015-1017.




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