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2012, Number 4

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Rev Med Inst Mex Seguro Soc 2012; 50 (4)

B lymphocyte stimulator in systemic lupus erythematosus

Mercado U

Language: Spanish
References: 8
Page: 349-350
PDF size: 22.44 Kb.


ABSTRACT

The B lymphocyte stimulator (BLyS) is an essential protein for the growth and survival of B cells. BLyS is expressed on monocytes, macrophages, and dendritic cells. BLyS binds to three receptors on B cells: BAFF-R, BCMA, and TACI. BLyS overexpression in mice leads to lupus-like syndrome, but not in all, whereas BLyS deficient mice results in a block of B cell development. High serum levels of BLyS can be detected in patients with lupus and rheumatoid arthritis. BLyS antagonists are an attractive target for treating autoimmune diseases.


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