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2011, Number 2

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Rev Med MD 2011; 2.3 (2)

Secondary syphilis resembling Non Hodgkin Lymphoma in a patient with HIV/AIDS

Mercado–Núñez E, González-Landeros M

Language: Spanish
References: 17
Page: 132-135
PDF size: 866.23 Kb.


ABSTRACT

47 year old male diagnosed with HIV since 2002, currently stage AIDS C2 with a medical history of lymph node tuberculosis and positive serologies for type B and C hepatitis and negative for VDRL (Venereal Disease Research Laboratory) in 2007. In 2009 the patient presents a tongue mass with an ulcerated necrotic center, but without purulent material. A biopsy is performed and histopathology reports NHL, for which chemotherapy is started. No improvement is shown in regards of the tongue mass a month after the first cycle of chemotherapy, furthermore patient shows a generalized dermatosis conformed by indurated erythematous papules which lead to the diagnostic suspicion of secondary syphilis. Serologies are requested and diagnosis of syphilis is obtained. Patient shows radicalimprovementto treatment. In the last two decades few case reports have described atypical presentations of secondary syphilis initially behaving as malignant lymphoproliferative disorders. This pattern has been described in patients with or without HIV.


REFERENCES

  1. K. Ranganathan and R. Hemalatha. Oral Lesions in HIV Infection in Developing Countries: an Overview. ADR April 2006 19: 63-68, doi:10.1177/154407370601900113

  2. Geddes A, Savin J, White SJ, Gibson J. Primary cutaneous CD8-positive Tcelllymphoma: a case report of a rare and aggressive disease with oral presentation. Dent Update. 2011 Sep;38(7):472-4, 476.

  3. P. Castellarin, G. Pozzato, G. Tirelli, R. Di Lenarda, y M. Biasotto. Oral Lesions and Lymphoproliferative Disorders. J Oncol 2010, pii: 202305. Epub 2010 Sep 1.

  4. Rodriguez y Nieto et al. Sífilis secundaria nodular en paciente VIH positivosimulando linfoma cutáneo. An Med Interna 2004; 21(5):241-243, 2004

  5. Lukehart SA. Chapter 169.Syphilis. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL,Loscalzo J, eds. Harrison's Principles of Internal Medicine. 18 th ed. New York: McGraw-Hill; 2011. http://eresources.library.mssm.edu:2059/content.aspx?aID=9102029. AccessedNovember 14, 2011.

  6. Conde-González, Valdespino, Juárez-Figueroa, Palma, Olamendi-Portugal,Olaiz-Fernández et al. Prevalencia de anticuerpos antitreponémicos y características sociodemográficas de la población mexicana adulta en el año 2000. Salud Pública Méx 2007; 49(sup 3):412-420

  7. Scott CM, Flint SR. Oral syphilis – re-emergence of an olddisease with oral manifestations. Int J Oral Maxillofac Surg 2005;34: 58–63.

  8. M. Ye´benes, A. Toll, A. Gime´nez-Arnau, M. Ferran, E. Parera, J. Fraga, C. etal. Pseudotumoral primary syphilis on the tongue in an HIV positive patient. España; Clin Exp Dermatol 2008;33:500–522

  9. Dalmau y Alegre et al. Syphilitic nodules on the tongue. J Am Acad Dermatol 2006 Feb;54(2 Suppl):S59-60. ;54(2).

  10. Dalmau J, Alegre M, et al. Nodules on the tongue in an HIV-positive patient. Barcelona, Spain. Scand J Infect Dis 2006;38(9):822-5.

  11. Spornraft-Ragaller P, Boashie U, et al. Spätsekundäre Syphilis mitUlzeration der Zungebei HIV-Koinfektion. Hautarzt 2006;57:1005–1008.

  12. Ikenberg K, Springer E, Bräuninger W, Kerl K, Mihic D, Schmid S, Schmitt A, Yeginsoy S, Bode B, Weber A. Oropharyngeal lesions and cervical lymphadenopathy: syphilis is a differential diagnosis that is still relevant.J Clin Pathol 2010 Aug;63(8):731-6.

  13. Breznik V, Potočnik M, Miljković J. Papulonodular secondary syphilis in a 52-year-old non-HIV heterosexual patient. Acta Dermatovenerol Alp Panonica Adriat. 2010 Dec;19(4):27-30

  14. Hyung-Sik Moon, MD y Kun Park, MD et al. A Nodular Syphilid Presenting as a Pseudolymphoma: Mimicking a Cutaneous Marginal Zone B-Cell Lymphoma. Am J Dermatopathol 2009;31(8):846-8.

  15. Liotta EA, Turiansky GW, Berberian BJ, Sulica VI, Tomaszewski MM. Unusual presentation of secondary syphilis in 2 HIV-1 positive patients. Cutis. 2000 Nov;66(5):383-6, 389.

  16. Calista y Valenzano et al. Unusual cutaneous presentation of ALK+ anaplastic large cell lymphoma mimicking syphilis on the glans penis. Eur J Dermatol. 2009 Jan-Feb;19(1):76-7.

  17. Leah J Blank y Anne M Rompalo. Treatment of syphilis in HIV-infected subjects: a systematic review of the literature. Sex Transm Infect. 2011 Feb;87(1):9-16. Epub 2010 Oct 5.




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