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2002, Number 1

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Rev Med Hosp Gen Mex 2002; 65 (1)

B19 Parvovirus

Aristi UG

Language: Spanish
References: 46
Page: 30-35
PDF size: 133.14 Kb.


ABSTRACT

B19 parvovirus is the only recognized pathogenic species in humans. Primary infection occurs more often in childhood. It infects erythroblasts and inhibits their mitotic activity with the consequent erythropoietic arrest. Clinical presentation depends of the immuno-hematological status of the patient. In normal hosts, infection is asymptomatic or causes mild anemia, erythema infectiosum, or self-limited arthropathy. In contrast, infection is usually severe in shick patients. High risk groups are constituted by patients with anemia (primarily hemolytic), immunodeficient and fetuses. Laboratory diagnosis for detection of the virus or its DNA includes immunohistochemistry, in situ hybridization and PCR. Other methods such as ELISA can be performed in order to demonstrate specific antibodies in serum. The presence of large intranuclear inclusions bodies in erythroblasts is the most important finding by light microscopy. At this time, there is no specific therapy against PB19; however, the development of a recombinant vaccine is in progress. Since PB19 infected patients with chronic anemia or immunodeficiency has been considered the primary source of infection, isolation of these patients must be recommended. The state of knowledge and research work concerning the PB19 has increased considerably in the last few years, and there is evidence that might be associated with many other diseases.


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