2012, Number 2
<< Back Next >>
Rev Cub Oftal 2012; 25 (2)
Effectiveness of the corneal collagen crosslinking in the treatment of keratoconus
Jareño OM, Pérez PZ, Fernández GK, Fernández DTM, Gómez CZ, Escalona LE, Díaz RS
Language: Spanish
References: 23
Page:
PDF size: 322.56 Kb.
ABSTRACT
Objective: to determine the effectiveness of corneal collagen crosslinking in patients with progressive keratoconus performed at “Ramón Pando Ferrer” Cuban Institute of Ophthalmology.
Methods: a retrospective and descriptive study was performed in 30 patients (30 eyes) with progressive keratoconus, who underwent the corneal collagen crosslinking. Data were collected preoperatively on one month, 3 months, 6 months and one year. The studied variables were age, sex, stage of keratoconus, best corrected visual acuity, spherical equivalent, maximum topographic keratometry, some topographic indexes of keratoconus diagnosis, coma and optical pachymetry.
Results: the female sex, the 20-29 y age group and the keratoconus stage II prevailed. The best corrected visual acuity increased from 0.65 ± 0.25 preoperatively to 0.74 ±0.23 after a year. The spherical equivalent decreased from -7.25 ± 4.48 to -6.39 ±4.20 diopters. The maximum topographic keratometry lowered from 50.76 ± 3.81 to 49.26 ±3.31 diopters. The topographic indexes were reduced. The coma error changed from 0.59 ±0.43 to 0.45 ±0.32 microns. Optical pachymetry of the pupil center ranged from 494 ±39.75 to 466 ±44.24 microns and thinner position of 484 ±45.86 to 450 ±51.12 microns. All results showed statistically significant differences in the first year.
Conclusions: crosslinking is an effective treatment for progressive keratoconus that allows interrupting the evolution of this ectatic disease.
REFERENCES
Torres RM, Merayo-Lloves J, Jaramillo MA, Galvis V. Biomecánica de la córnea. Arch Soc Esp Oftalmol. 2005;80(4):215-23.
Mora Valencia M, Bonilla Estévez C, Vargas Garzón O, Giraldo Valencia OL. Queratocono: una revisión y posible situación epidemiológica en Colombia. Ciencias Biomédicas. 2007;5(8):101-212.
Oxlund H, Simonsen AH. Biochemical studies of normal and keratoconus corneas. Acta Ophthalmol. 1985;63(6):6669.
Kenney MC. Causes of keratoconus. En: Boxer Wachler BS, editor. Manejo moderno del Queratocono. Nueva Delhi: Jaypee-Highlight Medical Publisher; 2009. p. 5-10.
Jareño Ochoa M, Escalona Leyva E, López Hernández S, Castillo Pérez A, Pérez Parra Z, Márquez Villalón S. Comportamiento de los trasplantes de cornea. Rev cubana Oftalmol. 2009;22 Suppl 2:47-51.
Wollensak GE, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135(5): 620-7.
Wollensak GE, Sporl E, Reber F, Pillunat L, Funk R. Corneal endotelial cytotoxicity of riboflavin/UVA treatment in vitro. Ophthalmic Res. 2003;35(6):324-8.
Wollensak GE, Wilsch M, Spoerl E, Seiler T. Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA. Cornea. 2004;23(5):503-7.
Wollensak GE, Aurich H, Pham DT, Wirbelauer C. Hydration behavior of porcine cornea crosslinked with riboflavin and ultraviolet A. J Cataract Refract Surg. 2007;33(3):516-21.
Wollensak G, Aurich H, Wirbelauer C, Sel S. Significance of the riboflavin film in corneal collagen crosslinking. J Cataract Refract Surg. 2010;36(1):114-20.
Caporossi A, Baiocchi S, Mazzotta C, Traversi C, Caporossi T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg. 2006;32(5):83745.
Mazzotta C, Traversi C, Baiocchi S, Caporossi O, Bovone C, Sparano MC, et al. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol. 2008;146(4):52733.
Caporossi A, Mazzotta C, Baiocchi S, Caporossi T. Long-term Results of Riboflavin Ultraviolet A Corneal Collagen Cross-linking for Keratoconus in Italy: The Siena Eye Cross Study. Am J Ophthalmol. 2010;149(4):58593.
Coskunseven E, Jankov MR, Hafezi F. Contralateral eye study of corneal collagen cross-linking with riboflavin and UVA irradiation in patients with keratoconus. J Refract Surg. 2009;25(4):371-6.
Agrawal VB. Corneal collagen cross-linking with riboflavin and ultraviolet-A light for keratoconus: Results in Indian eyes. Indian J Ophthalmol. 2009;57(2):1114.
Vinciguerra P, Albè E, Trazza S, Rosetta P, Vinciguerra R, Seiler T, et al. Refractive, Topographic, Tomographic, and Aberrometric Analysis of Keratoconic Eyes Undergoing Corneal Cross-Linking. Ophthalmology. 2009;116(3):36978.
Wittig-Silva C, Whiting M, Lamoureux E, Lindsay RG, Sullivan LJ, Snibson GR, et al. A randomized controlled trial of corneal crosslinking in progressive keratoconus: preliminary results. J Refract Surg. 2008;24(7):S720-25.
Raiskup-Wolf F, Hoyer A, Spoerl E. Pillunat LE. Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: Long-term results. J Cataract Refract Surg. 2008;34(5):796801.
Maeda N, Fujikado T, Kuroda T, Miháhi T, Hirohara Y, Nishida Y, et al. Wave front aberrations measured with Hartmann-Shack sensor in patients with keratoconus. Ophthalmology. 2002;109(11):1996-2003.
Alio JL, Shabayek MH. Corneal Higher Order Aberrations: A Method to Grade Keratoconus. J Refract Surg. 2006;22(6):539-45.
McDonald MB. Estudio multicéntrico produce datos prometedores sobre cross-linking corneal para córneas ectáticas. Corneal external disease. Ocular Surgery News Latin America Edition. 2010 octubre 1.
Wollensak G, Redl B. Gel eletrophoretic analysis of corneal collagen after photodynamic cross-linking treatment. Cornea. 2008;27(3):3536.
Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T. Safety of UVA-riboflavin cross-linking of the cornea. Cornea. 2007;26(4):3859.