Pérez GY, Pagura L, Fiandesio C, Cortés LL

Language: Spanish
References: 29
Page: 220-225
PDF size: 188.31 Kb.

ABSTRACT

Histiocytic sarcoma is defined by the WHO as a malignant proliferation of cells showing morphologic and immunophenotypic features of mature tissue histiocytes. Case report: A 37-year-old male who presented weight loss and diarrhea of six months duration. The ultrasound study showed a splenic tumor. Therefore, the spleen was removed. At microscopic examination a pleomorphic cellular proliferation was observed with spindle-shaped areas arranged in bundles and areas of solid growth. The inmunohistochemistry study was positive for CD68, CD4, lysozyme, alfa 1 antitrypsin and vimentin. Histiocytic sarcoma represents less than 1% of all tumors affecting the lymph nodes and soft tissues. Being very rare in splenic location, its etiology is unknown. It is manifested as unique tumors associated with systemic symptoms and the prognosis is grim.

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