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Patología Revista Latinoamericana

2012, Number 3

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Patol Rev Latinoam 2012; 50 (3)

Intradermal Nevus cells Histopathogenesis. Abtropfung versus Hochsteigerung

Rodríguez-Martínez HA, Rodríguez-Reyes AA, Chávez-Mercado L, López-Vancell D, Pérez-Olvera O, Valles-Valles DR, Maldonado-Hernández GA

Language: Spanish
References: 39
Page: 206-213
PDF size: 149.50 Kb.


ABSTRACT

In this essay we present a historical review of efforts to elucidate the histogenesis of intradermal nevus cells and the pathogenesis of intradermal nevi. These contributions embrace from Unna´s Abtropfung or dropping off, going through Masson´s dual origin (melanocytic and schwannian) as well as Cramer´s Hochsteigerung or ascension of the cells, up to Rosai´s unifying concept of three atavistic lesions originated from the neural crest, which display a combination of peripheral nerve endings and neuroendocrine cells. Such lesions are: carcinoid tumors from the tip of obliterated appendices, gangliocytic paragangliomas of the ampulla of Vater and cutaneous intradermal nevi. Furthermore, abundant information was brought together, apparently irrelevant and disconnected, which as a whole provide important arguments that contribute to solve the problem. From our review, we drew the following three conclusions (hypotheses?): a) intradermal nevus cells originate, directly or indirectly, from the neural crests and not from the dermo-epidermal melanocytes through the Abtropfung; b) human intradermal nevi may be considered as organoid benign neoplasms of neural lineage, hamartomatous or choristomatous nature and atavistic origin; and c) it is unwarranted to designate intradermal nevi as “melanocytic nevi”, because they are neoplasias which are neither originated from nor composed by melanocytes.


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