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Patología Revista Latinoamericana

2012, Number 3

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Patol Rev Latinoam 2012; 50 (3)

Disorders of cerebellar growth and development in preterm neonates. A neuropathological study

Jones M, Mijalovsky A, Valencia M

Language: Spanish
References: 88
Page: 190-205
PDF size: 543.32 Kb.


ABSTRACT

In order to evaluate postnatal development of cerebellum, we analyzed 92 cerebella from preterm and term neonates up to 7 days postnatal age (control cases) and preterm neonates with postconceptional age at term equivalent. Reduction of the cerebellar weight, diminished foliar height and foliation, diminished molecular layer thickness, diminished internal granular layer cell density, and high number of Purkinje cells per segment were observed. These results correlated with each other and with brain and body weight, but not with gestational age. Necrosis, apoptosis in the immature cortex, reactive astrocytosis and microgliosis in the white matter correlated with hypoxia-ischemia, infections, undernutrition and therapies. The cases examined showed cerebellar lesions plus underdeveloped cerebellar structures with patterns similar to those of 30-35 weeks gestational age, although these preterm neonates had completed a postconceptional age equivalent to term. We interpreted the findings as the effect of noxa acting during the cerebellar lobes’ vulnerability window. Direct injury of developing cerebellar cortex and white matter is an important though poorly recognized cause of impaired cerebellar growth.


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