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2004, Number 2

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Rev Med Hosp Gen Mex 2004; 67 (2)

Leukocytosis-hypercalcemia syndrome associated to penis epidermoid carcinoma. Presentation of a case

Santiago-Prieto AC, Soriano-Rosas J, Calvo-Ibarrola JB, Guevara-López B, Carrera-González E, Durán-Padilla MA

Language: Spanish
References: 18
Page: 98-103
PDF size: 142.91 Kb.


ABSTRACT

A paraneoplastic syndrome of leucocytosis and hypercalcemia, has been associated with squamous carcinomas, in which has been demonstrated the presence of granulocytes and macrophages colony stimulating factors, interleukin- 1 and tumor necrosis factor. A case of a 51 years old man with penis squamous carcinoma and metastasis in groin lymph nodes, associated to hypercalcemia anatomic manifestations (nephrocalcinosis and pulmonary metastatic calcification) and bone resorption, is reported. The neoplasic cells were positive at immunoperoxidase reaction for tumor necrosis factor. We propose that this factor secretion by neoplastic cells, may be responsible for the hypercalcemia- leucocytosis syndrome.


REFERENCES

  1. Maldonado J. Tratamiento del cáncer de pene. Rev Med Hosp Gen 1970; 33: 633-640.

  2. Registro Histopatológico de Neoplasias Malignas. Compendio de Mortalidad y Morbilidad 1998. Secretaría de Salud. Subsecretaría de Prevención y Control de Enfermedades. Coordinación de Vigilancia Epidemiológica. Dirección General de Epidemiología.

  3. Cotran R, Kumar V, Collins T. Robbins. Patología estructural y funcional. 6a ed. México: McGraw Hill- Interamericana, 2000.

  4. Bunn PA, Minna JD. Paraneoplastic syndromes. En: De Vita VT. Cancer, principles and practice of oncology. Philadelphia: Lippincott, 1985; 1797-1842.

  5. Sato K, Fujii Y, Shizume K. Paraneoplastic syndrome of hypercalcemia and leucocytosis caused by squamous carcinoma cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1a and granulocyte colony-stimulating factor. Cancer Res 1989; 49 (17): 4740-4746.

  6. Fan K, Smith DJ. Hypercalcemia associated with renal cell carcinoma: Probable roll of neoplastic stromal cells. Hum Pathol 1983; 14: 168.

  7. Burtis WJ, Brady TG, Orloff JJ, Ersbak JB, Warrell RP Jr, Olson BR et al. Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. N Engl J Med 1990; 322: 1106.

  8. Budayr AA, Nissenson RA, Klein RF, Pun KK, Clark OH, Diep D et al. Increased serum levels of a parathyroid hormone like protein in malignancy-associated hypercalcemia. Ann Intern Med 1989; 11: 807.

  9. Stewart AE, Vignery A, Silverglat A, Ravin ND, Li Volsi et al. Quantitative bone histomorphometry in humoral hypercalcemia of malignancy: Uncoupling of bone- cell activity. Metab 1982; 55: 219.

  10. Heptinstall RH. Pathology of the kidney. 4th ed. Boston: Little Brown, 1992.

  11. Saito K, Y Kuratomi K, Yamamoto T, Saito T, Kusuya S, Yoshida S et al. Primary squamous cell carcinoma of the thyroid associated with marked leukocytosis and hypercalcemia. Cancer (Phila) 1981; 48: 2080-2083.

  12. Kondo Y, Sato K, Ohkwa H, Ueyama Y, Okabe T, Sato N et al. Association of hypercalcemia with tumors producing colony stimulating factor (s). Cancer Res 1983; 43: 2368-2374.

  13. Yoneda T, Asina M, Chavez J, Bonewald L, Nishimura R, Mundy G. Evidence that tumor necrosis factor plays a pathogenic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice. J Clin Invest 1991; 87: 977-985.

  14. Pfeilschifter J, Chenu C, Bird A, Mundy GR, Roodman GD. Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclast-like cells in vitro. J Bone Miner Res 1989; 4: 113-118.

  15. Sato K, Mimura H, Han DC, Kakiuchi T, Ueyama Y, Ohkawa H et al. Production of bone resorbing activity and colony-stimulating activity in vivo and in vitro by a human squamous cell carcinoma associated with hypercalcemia and leukocytosis. J Clin Invest 1986; 78: 145-154.

  16. Yoneda T, Nishikawa N, Nishimura R, Kato I, Sakuda M. Three cases of oral squamous cancer associated with leukocytosis, hypercalcemia or both. Oral Surg Oral Med Oral Pathol 1989; 68: 604-611.

  17. Hasleton P. Pathology of the lung. 5th ed. New York, NY: Mc Graw Hill, 1996.

  18. Mac Ewan D. TNF receptor subtype signalling: Differences and cellular consequences. Cel Signal 2002; 14: 477.




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