2004, Number 1
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Rev Med Hosp Gen Mex 2004; 67 (1)
Pulmonary features in systemic lupus erythematosus. A brief review
Zambrano GJA, Rangel CCA, Novelo RV, Martínez-Cordero E
Language: Spanish
References: 38
Page: 41-49
PDF size: 627.99 Kb.
ABSTRACT
Pulmonary manifestations are frequent findings in systemic lupus erythematosus. The broad distribution of organ involvement which include the presence of several pleural, vascular and interstitial abnormalities may explain, at least in part, the diversity and heterogeneous appearance of lung disease in this autoimmune disorder. An accurate differential diagnosis by the clinician is essential to distinguish specific lung abnormalities during the study of this multisystemic disease. In particular, it is important to distinguish the respiratory changes that are related to the physiopathological mechanism of systemic lupus erythematosus from other abnormalities in which the autoimmune process did not play a significant role, like infectious disease of different etiology as well as hypersensitivity lung disease and interstitial pneumonitis. In addition to those lung complaints directly related to systemic lupus erythematosus, several reports emphasize the frequent appearance of respiratory abnormalities secondary to renal failure, heart disease and immunosuppressive treatment. Indeed, acute pneumonitis, pulmonary hypertension, thromboembolic disease, as well as lung hemorrhage and fibrosis may occur during the evolution of systemic lupus erythematosus, particularly in those patients who have severe complications. The aim of this review is emphasize though a case report, the relevance to establish a differential diagnosis of lung disease in systemic lupus erythematosus. It also pointed out that a well-organized multidisciplinary approach is important for studying the pulmonary manifestations in autoimmune multisystemic disorders.
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