2004, Number 1
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Rev Med Hosp Gen Mex 2004; 67 (1)
Primary autoimmune inner ear disease. Six year follow-up case report
López-Vázquez M, Arce-Salinas A
Language: Spanish
References: 7
Page: 32-35
PDF size: 80.11 Kb.
ABSTRACT
We report a case of autoimmune inner ear disease with six years follow-up in a 46 year old man. The clinical suspicion of this disease characterized by a rapidly progressive bilateral sensorineural hearing loss, was confirmed by the presence of HSP 70 (
Heat shock protein) antibodies; the unique laboratory test that until now , has been correlated in some cases with this disease. In this case, no other autoimmune diseases concurred. The good response with immune suppressant treatment and the relapse, even to worse degree of hearing loss, observed when treatment was suspended, confirms the immune-mediated origin of the disease.
REFERENCES
Harris JP, Heydt J, Keithley EM et al: Immunopathology of the inner ear: An update. Ann NY Acad Sci 1997; 830: 166-178.
Harris JP, Fukuda S, Keithley EM: Spiral modiolar vein: Its importance in inner ear inflammation. Acta Otolaryngol (Stockh) 1990; 110: 357-365.
Harris JP, Ryan AF: Fundamental immune mechanisms of the brain and inner ear. Otolaryngol Head Neck Surg 1995; 112: 639-653
McCabe BF: Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 1979; 88: 585-589.
Hughes GB, Moscicki R, Barna BP et al: Laboratory diagnosis of immune inner ear disease. Am J Otol 1994; 15: 198-202.
Moscicki RA, San Martin JE, Quintero CH et al: Serum antibody to inner ear proteins in patients with progressive hearing loss. Correlation with disease activity and response to corticosteroid treatment. JAMA 1994; 272: 611-616.
Gottschlich S, Billings PB, Keithley EM et al: Assessment of serum antibodies in patients with rapidly progressive sensorineural hearing loss and Meniere’s disease. Laryngoscope 1995; 105: 1347-1352.