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2007, Number 4

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Rev Educ Bioquimica 2007; 26 (4)

'¡Silencio mensajeros! Qué son y cómo actúan los microRNAs'

Flores F, Martínez MÁ, Arenas C, Covarrubias A, Reyes JL

Language: Spanish
References: 16
Page: 135-141
PDF size: 170.68 Kb.


ABSTRACT

MicroRNAs are short RNA molecules that base-pair to complementary regions in target messenger RNAs. Binding of microRNAs results in the inhibiton of target mRNA expression, termed RNA silencing. Here, we will review recent progress in the identification, biogenesis genomic arrangement and mechanisms of action of plant and animal microRNAs. In addition, we will present other small RNAs found in both plants and animals that have also been proposed as regulators of gene expression as well. Finally, we highlight what we consider to be current questions in the field, as important challenges for future researchers.


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